| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-01-24 |
| タイトル |
|
|
タイトル |
In Vivo Efficacy of Curcumin and Curcumin Nanoparticle in Trypanosoma congolense, Broden 1904 (Kinetoplastea: Trypanosomatidae)-Infected Mice |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
animal African trypanosomosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
drug discovery |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
nanomedicine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
natural products |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
phytomedicine |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Molefe-Nyembe, Nthatisi Innocentia
Adeyemi, Oluyomi Stephen
近藤, 大輔
加藤, 健太郎
井上, 昇
菅沼, 啓輔
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| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Curcumin (CUR) is known for its wide folkloric effects on various infections; however, its solubility status has remained a hindrance to its bioavailability in the host. This study evaluated the comparative effects of CUR and CUR-nanoparticle in vitro on T. congolense, T. b. brucei, and T. evansi. Additionally, CUR and CUR-nanoparticle anti-Trypanosoma efficacy were assessed in vivo against T. congolense. All the CUR-nanoparticles were two folds more effective on the T. congolense as compared to CUR in vitro, with recorded efficacy of 3.67 ± 0.31; 7.61 ± 1.22; and 6.40 ± 3.07 μM, while the CUR-nanoparticles efficacy was 1.56 ± 0.50; 28.16 ± 9.43 and 13.12 ± 0.13 μM on T. congolense, T. b. brucei, and T. evansi, respectively. Both CUR and CUR-nanoparticles displayed moderate efficacy orally. The efficacy of CUR and CUR-nanoparticles in vivo was influenced by solubility, presence of food, and treatment period. CUR-treated mice were not cured of the infection; however, the survival rate of the orally treated mice was significantly prolonged as compared with intraperitoneal-treated mice. CUR-nanoparticles resulted in significant suppression of parasitemia even though relapsed was observed. In conclusion, CUR and CUR-nanoparticles possess moderate efficacy orally on the trypanosomes as compared to the intraperitoneal treatment. |
|
言語 |
en |
| 書誌情報 |
en : Pathogens
巻 12,
号 10,
p. 1227,
発行日 2023-10-09
|
| 出版者 |
|
|
出版者 |
Multidisciplinary Digital Publishing Institute (MDPI) |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2076-0817 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/pathogens12101227 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
言語 |
ja |
|
主題Scheme |
NDC |
|
主題 |
649 |
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