{"created":"2024-01-24T01:13:30.678381+00:00","id":2000119,"links":{},"metadata":{"_buckets":{"deposit":"0a9b44e1-da05-49f6-a352-c4d8b37fc604"},"_deposit":{"created_by":12,"id":"2000119","owner":"12","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"2000119"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:02000119","sets":["5"]},"author_link":["329","79","63","357"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-10-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"1227","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Pathogens","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Curcumin (CUR) is known for its wide folkloric effects on various infections; however, its solubility status has remained a hindrance to its bioavailability in the host. This study evaluated the comparative effects of CUR and CUR-nanoparticle in vitro on T. congolense, T. b. brucei, and T. evansi. Additionally, CUR and CUR-nanoparticle anti-Trypanosoma efficacy were assessed in vivo against T. congolense. All the CUR-nanoparticles were two folds more effective on the T. congolense as compared to CUR in vitro, with recorded efficacy of 3.67 ± 0.31; 7.61 ± 1.22; and 6.40 ± 3.07 μM, while the CUR-nanoparticles efficacy was 1.56 ± 0.50; 28.16 ± 9.43 and 13.12 ± 0.13 μM on T. congolense, T. b. brucei, and T. evansi, respectively. Both CUR and CUR-nanoparticles displayed moderate efficacy orally. The efficacy of CUR and CUR-nanoparticles in vivo was influenced by solubility, presence of food, and treatment period. CUR-treated mice were not cured of the infection; however, the survival rate of the orally treated mice was significantly prolonged as compared with intraperitoneal-treated mice. CUR-nanoparticles resulted in significant suppression of parasitemia even though relapsed was observed. In conclusion, CUR and CUR-nanoparticles possess moderate efficacy orally on the trypanosomes as compared to the intraperitoneal treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Multidisciplinary Digital Publishing Institute (MDPI)","subitem_publisher_language":"en"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/pathogens12101227","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 by the authors. Licensee MDPI, Basel, Switzerland.","subitem_rights_language":"en"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2076-0817","subitem_source_identifier_type":"EISSN"}]},"item_2_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"649","subitem_subject_language":"ja","subitem_subject_scheme":"NDC"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Molefe-Nyembe, Nthatisi Innocentia","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Adeyemi, Oluyomi Stephen","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kondoh, Daisuke","creatorNameLang":"en"},{"creatorName":"近藤, 大輔","creatorNameLang":"ja"}],"familyNames":[{"familyName":"Kondoh","familyNameLang":"en"},{"familyName":"近藤","familyNameLang":"ja"}],"givenNames":[{"givenName":"Daisuke","givenNameLang":"en"},{"givenName":"大輔","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"329","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002683176","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002683176"},{"nameIdentifier":"90708364","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90708364"},{"nameIdentifier":"0000-0002-3015-5156","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-3015-5156"}]},{"creatorNames":[{"creatorName":"Kato, Kentaro","creatorNameLang":"en"},{"creatorName":"加藤, 健太郎","creatorNameLang":"ja"}],"familyNames":[{"familyName":"Kato","familyNameLang":"en"},{"familyName":"加藤","familyNameLang":"ja"}],"givenNames":[{"givenName":"Kentaro","givenNameLang":"en"},{"givenName":"健太郎","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"79","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002888049","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002888049"},{"nameIdentifier":"30401178","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30401178"}]},{"creatorNames":[{"creatorName":"Inoue, Noboru","creatorNameLang":"en"},{"creatorName":"井上, 昇","creatorNameLang":"ja"}],"familyNames":[{"familyName":"Inoue","familyNameLang":"en"},{"familyName":"井上","familyNameLang":"ja"}],"givenNames":[{"givenName":"Noboru","givenNameLang":"en"},{"givenName":"昇","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"63","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002841346","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002841346"},{"nameIdentifier":"10271751","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10271751"},{"nameIdentifier":"read0185948","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/read0185948"}]},{"creatorNames":[{"creatorName":"Suganuma, Keisuke","creatorNameLang":"en"},{"creatorName":"菅沼, 啓輔","creatorNameLang":"ja"}],"familyNames":[{"familyName":"Suganuma","familyNameLang":"en"},{"familyName":"菅沼","familyNameLang":"ja"}],"givenNames":[{"givenName":"Keisuke","givenNameLang":"en"},{"givenName":"啓輔","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"357","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000345306716","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000345306716"},{"nameIdentifier":"60772184","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60772184"},{"nameIdentifier":"11922960","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/11922960"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-01-24"}],"filename":"suganuma_pathogens-12-01227-v2.pdf","filesize":[{"value":"7 MB"}],"format":"application/pdf","licensetype":"license_0","url":{"label":"fulltext","url":"https://obihiro.repo.nii.ac.jp/record/2000119/files/suganuma_pathogens-12-01227-v2.pdf"},"version_id":"1f1d037b-42ee-4cbe-9e04-e539867c2ac1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"animal African trypanosomosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"drug discovery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nanomedicine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"natural products","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phytomedicine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In Vivo Efficacy of Curcumin and Curcumin Nanoparticle in Trypanosoma congolense, Broden 1904 (Kinetoplastea: Trypanosomatidae)-Infected Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In Vivo Efficacy of Curcumin and Curcumin Nanoparticle in Trypanosoma congolense, Broden 1904 (Kinetoplastea: Trypanosomatidae)-Infected Mice","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-01-24"},"publish_date":"2024-01-24","publish_status":"0","recid":"2000119","relation_version_is_last":true,"title":["In Vivo Efficacy of Curcumin and Curcumin Nanoparticle in Trypanosoma congolense, Broden 1904 (Kinetoplastea: Trypanosomatidae)-Infected Mice"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-12-04T02:19:06.479924+00:00"}