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Evaluation of the inhibitory effect of N-acetyl-L-cysteine on Babesia and Theileria parasites
https://obihiro.repo.nii.ac.jp/records/4170
https://obihiro.repo.nii.ac.jp/records/417003b01925-e181-40ae-a95e-7af48da9b5dd
名前 / ファイル | ライセンス | アクション |
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fulltext (245.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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公開日 | 2018-03-07 | |||||||||||||
タイトル | ||||||||||||||
言語 | en | |||||||||||||
タイトル | Evaluation of the inhibitory effect of N-acetyl-L-cysteine on Babesia and Theileria parasites | |||||||||||||
言語 | ||||||||||||||
言語 | eng | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Babesia | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Theileria | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | N-acetyl-L-cysteine | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | In vitro | |||||||||||||
資源タイプ | ||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
資源タイプ | journal article | |||||||||||||
著者 |
Rizk, Mohamed Abdo.
× Rizk, Mohamed Abdo.× El-Sayed, Shimaa Abd El-Salam× AbouLaila, Mahmoud× 横山, 直明
WEKO
312
× 五十嵐, 郁男
WEKO
58
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抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | N-acetyl-L-cysteine is known to have antibacterial, antiviral, antimalarial, and antioxidant activities. Therefore, the in vitro inhibitory effect of this hit was evaluated in the present study on the growth of Babesia and Theileria parasites. The in vitro growth of Babesia bovis, Babesia bigemina, Babesia divergens, Theileria equi, and Babesia caballi that were tested was significantly inhibited (P < 0.05) by micromolar concentrations of N-acetyl-L-cysteine. The inhibitory effect of N-acetyl-L-cysteine was synergistically potentiated when used in combination with diminazene aceturate on B. bovis and B. caballi cultures. These results indicate that N-acetyl-L-cysteine might be used as a drug for the treatment of babesiosis, especially when used in combination with diminazene aceturate. (C) 2017 Elsevier Inc. All rights reserved. | |||||||||||||
言語 | en | |||||||||||||
書誌情報 |
en : Experimental Parasitology 巻 179, p. 43-48, 発行日 2017-08 |
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出版者 | ||||||||||||||
言語 | en | |||||||||||||
出版者 | Elsevier | |||||||||||||
ISSN | ||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||
収録物識別子 | 00144894 | |||||||||||||
書誌レコードID | ||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||
収録物識別子 | AA00641226 | |||||||||||||
DOI | ||||||||||||||
関連タイプ | isVersionOf | |||||||||||||
識別子タイプ | DOI | |||||||||||||
関連識別子 | info:doi/10.1016/j.exppara.2017.06.003 | |||||||||||||
権利 | ||||||||||||||
言語 | en | |||||||||||||
権利情報 | This accepted manuscript is licensed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. <http://creativecommons.org/lisenses/by-nc-nd/4.0/> | |||||||||||||
フォーマット | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | application/pdf | |||||||||||||
著者版フラグ | ||||||||||||||
出版タイプ | AM | |||||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
日本十進分類法 | ||||||||||||||
主題Scheme | NDC | |||||||||||||
主題 | 491 |