Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2024-05-20 |
タイトル |
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言語 |
en |
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タイトル |
In vitro regulation of gene expression of pregnancy-associated proteins and cytokines in bovine endometrial epithelial cells and bovine trophoblastic cells by infection with Neospora caninum |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Bovine |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Neospora caninum |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Trophoblastic cells |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Uterine epithelial cells |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
著者 |
Abdelbaky, Hanan H.
Shimoda, Naomi
Akthar, Ihshan
Nakamura, Shu
Hasan, Md Hasibul
Ushio, Nanako
宮本, 明夫
西川, 義文
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Abortion caused by the parasite Neospora caninum is an important threat to the livestock industry worldwide. Trophoblasts and caruncular cells play major roles in initiating innate immune responses and controlling parasite infection at the fetal-maternal interface. In the present study, bovine uterine epithelial cells (BUECs) and bovine trophoblastic (BT) cells treated with bovine interferon-gamma (IFN-γ), IFN-alpha (IFN-α) and IFN-tau (IFN-τ) followed by infection with N. caninum were examined by measuring the mRNA expression levels of numerous pregnancy-associated proteins and observing parasite growth to elucidate the host-parasite interaction at the uteroplacental region. N. caninum infection increased the expression of prolactin-related protein 1 (PRP1), pregnancy-associated glycoprotein 1 (PAG1), and cytokines (TNF-α, IL-8 and IL-10) in BUECs and of IL-8 in BT cells. Bovine IFN-γ inhibited IL-8 and TNF-α expression in BUECs and IL-8 in BT cells. In contrast, the expression of the interferon-stimulated gene OAS1 was significantly increased by treatment of the infected BT cells with IFN-γ. However, treatment with bovine IFNs did not inhibit N. caninum growth in either cell line. In conclusion, our results suggest that bovine IFN-γ plays a crucial role in control of pathogenesis in uterus and induction of inflammatory response in the placental region following N. caninum infection, rather than growth inhibition of the parasites. © 2024 |
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言語 |
en |
書誌情報 |
en : Parasitology International
巻 101
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出版者 |
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言語 |
en |
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出版者 |
Elsevier Ireland |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
13835769 |
PubMed番号 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
PMID |
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関連識別子 |
38648880 |
DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.parint.2024.102898 |
権利 |
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言語 |
en |
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権利情報 |
Elsevier |
フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
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言語 |
en |
著者版フラグ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
日本十進分類法 |
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言語 |
ja |
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主題Scheme |
NDC |
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主題 |
649 |