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Candidacy of liver stage antigen-1 for Plasmodium falciparum vaccine development
https://obihiro.repo.nii.ac.jp/records/1533
https://obihiro.repo.nii.ac.jp/records/15335b91c386-370c-430c-944c-06eac258f42a
| 名前 / ファイル | ライセンス | アクション |
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Prot.Vol.11-1,2-1.pdf (449.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2006-12-19 | |||||||||
| タイトル | ||||||||||
| タイトル | Candidacy of liver stage antigen-1 for Plasmodium falciparum vaccine development | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | malaria | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Plasmodium falciparum | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | liver stage | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | vaccine | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cellular immunity | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Taylor-Robinson, Andrew W.
× Taylor-Robinson, Andrew W.
× Heal, Karen G.
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Malaria is the world's most important parasitic disease, imposing a massive health burden on people living in the tropics, often in the poorest countries. The vast majority of deaths in humans from malaria are caused by one species of the hemoprotozoan, Plasmodium falciparum., against which effective control measures are urgently needed. The global situation has deteriorated in recent times due to increased resistance of the anopheline mosquitoes that transmit P. falciparum to insecticides, and of the parasites themselves to drug therapy. An efficacious and cost-effective vaccine against this parasite is considered a public health priority. A vaccine that targets pre-erythrocytic parasites in the liver could potentially prevent clinical disease by blocking development of the pathogenic erythrocytic stage of the parasite's life cycle. Among around 40 known P. falciparum antigens, liver stage antigen-1 (LSA-1) is the only protein expressed exclusively by liver stage parasites. Independent studies in humans have consistently related immune responses to LSA-1 with resistance to malaria infection or disease, providing a powerful rationale for the development of liver stage vaccines based on LSA-1. By dissecting the mechanism(s) of immunity to this antigen, epitopes associated with protection can be evaluated in different delivery systems as components of a focused and coordinated multi-antigen malaria vaccine strategy. | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
en : The journal of protozoology research 巻 11, 号 1-2, p. 1-18, 発行日 2001-04 |
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| 出版者 | ||||||||||
| 出版者 | National Research Center for Protozoan Diseases | |||||||||
| 言語 | en | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 09174427 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA10824856 | |||||||||
| 権利 | ||||||||||
| 言語 | en | |||||||||
| 権利情報 | National Research Center for Protozoan Diseases | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 日本十進分類法 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 649 | |||||||||
