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Effect of aflatoxin B1 on the therapeutic efficacy of suramin in Trypanosoma brucei rhodesiense-infected mice
https://obihiro.repo.nii.ac.jp/records/1448
https://obihiro.repo.nii.ac.jp/records/144860c0b562-456c-418b-bc68-3ea75f2b2726
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Kibugu.pdf (463.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-02-29 | |||||
| タイトル | ||||||
| タイトル | Effect of aflatoxin B1 on the therapeutic efficacy of suramin in Trypanosoma brucei rhodesiense-infected mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Aflatoxin B1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | trypanosomiasis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | suramin efficacy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | mice | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kibugu, J.K.
× Kibugu, J.K.× Mdachi, R.E.× Kagira, J.M.× Muchiri, M.W.× Makumi, J.N.× Ngeranwa, J.J.N.× Auma, J. E.× Ngae, G.N. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Through immuno-suppression, aflatoxins could affect drug and vaccine efficacy. Such effects have not been evaluated in treatment of many diseases including trypanosomiasis. We assessed the effect of aflatoxin B1 on the efficacy of suramin, the drug used for treatment of early stage sleeping sickness, in a murine model. Mice were fed daily on a diet containing 0.50 mg aflatoxin/kg body weight or a placebo. They were infected with Trypanosoma brucei rhodesiense on day 7 post-aflatoxin exposure and then treated with one of 6 different doses of suramin (4.0, 4.5, 5.0, 5.5, 6.0 and 6.5 mg/kg body weight) at the onset of parasitemia. The mice were fed on aflatoxin diet for 30 days and the curative dose values (CD50, 75, and 90) computed and compared using a logistic linear regression model. Aflatoxin B1 induced transient protection of the host against T. b. rhodesiense infection and a consistent increase in suramin CD values in the mice suggesting reduced drug efficacy. Aflatoxicosis hindered curative treatment of T. b. rhodesiense infection in mice, and may contribute to reduced efficacy of suramin during treatment of sleeping sickness in man. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : The journal of protozoology research 巻 21, 号 2, p. 59-69, 発行日 2011-12 |
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| 出版者 | ||||||
| 出版者 | National Research Center for Protozoan Diseases | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 09174427 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10824856 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | National Research Center for Protozoan Diseases | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 649 | |||||
