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Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease
https://obihiro.repo.nii.ac.jp/records/1281
https://obihiro.repo.nii.ac.jp/records/128163f9fd3b-75ef-455c-834f-33ec5d6f7292
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S1347861317300580-main.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2017-10-27 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Memory extinction | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | MPTP-Treated mice | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Phosphodiesterase IV inhibitor rolipram | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Kinoshita, Ken-ichi
× Kinoshita, Ken-ichi× Muroi, Yoshikage× Unno, Toshihiro× Ishii, Toshiaki
WEKO
318
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Cognitive impairment often occurs in Parkinson's disease (PD), but the mechanism of onset remains unknown. Recently, we reported that PD model mice produced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show facilitation of hippocampal memory extinction, which may be the cause of cognitive impairment in PD. When we examined the cAMP/CREB signaling in the hippocampus, decreased levels of cAMP and phosphorylated CREB were observed in the dentate gyrus (DG) of MPTP-treated mice. Administration of rolipram improved the memory deficits with concomitant recovery of cAMP and phosphorylated CREB levels, suggesting that reduced cAMP/CREB signaling in the DG leads to cognitive impairment in MPTP-treated mice. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. | |||||||
言語 | en | |||||||
書誌情報 |
en : Journal of Pharmacological Sciences 巻 134, 号 1, p. 55-58, 発行日 2017-05 |
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出版者 | ||||||||
言語 | en | |||||||
出版者 | Japanese Pharmacological Society | |||||||
ISSN | ||||||||
収録物識別子タイプ | PISSN | |||||||
収録物識別子 | 13478613 | |||||||
書誌レコードID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA11806667 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | info:doi/10.1016/j.jphs.2017.04.002 | |||||||
権利 | ||||||||
言語 | en | |||||||
権利情報 | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
日本十進分類法 | ||||||||
主題Scheme | NDC | |||||||
主題 | 645 |