Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2017-10-27 |
タイトル |
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言語 |
en |
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タイトル |
Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Memory extinction |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
MPTP-Treated mice |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Phosphodiesterase IV inhibitor rolipram |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
著者 |
Kinoshita, Ken-ichi
室井, 喜景
Unno, Toshihiro
石井, 利明
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Cognitive impairment often occurs in Parkinson's disease (PD), but the mechanism of onset remains unknown. Recently, we reported that PD model mice produced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show facilitation of hippocampal memory extinction, which may be the cause of cognitive impairment in PD. When we examined the cAMP/CREB signaling in the hippocampus, decreased levels of cAMP and phosphorylated CREB were observed in the dentate gyrus (DG) of MPTP-treated mice. Administration of rolipram improved the memory deficits with concomitant recovery of cAMP and phosphorylated CREB levels, suggesting that reduced cAMP/CREB signaling in the DG leads to cognitive impairment in MPTP-treated mice. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. |
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言語 |
en |
書誌情報 |
en : Journal of Pharmacological Sciences
巻 134,
号 1,
p. 55-58,
発行日 2017-05
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出版者 |
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言語 |
en |
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出版者 |
Japanese Pharmacological Society |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
13478613 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11806667 |
DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
info:doi/10.1016/j.jphs.2017.04.002 |
権利 |
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言語 |
en |
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権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
日本十進分類法 |
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主題Scheme |
NDC |
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主題 |
645 |