| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-09-15 |
| タイトル |
|
|
タイトル |
Involvement of Host Defense Mechanisms against Toxoplasma gondii Infection in Anhedonic and Despair-Like Behaviors in Mice |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Toxoplasma gondii |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
1-methyl tryptophan |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
minocycline |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
interferon gamma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
sickness behavior |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
anhedonic behavior |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
despair-like behavior |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Mahmoud, Motamed Elsayed
Fereig, Ragab
西川, 義文
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Toxoplasma gondii is a pathogen relevant to psychiatric disorders. We recently showed that reactivation of chronic T. gondii infection induced depression-like behaviors in mice. Furthermore, it has been hypothesized that depression-like behaviors are mediated via a host defense mechanism against invading pathogens; proximate mechanisms of this behavioral hypothesis remain unclear. In the present study, we investigate the contribution of indoleamine 2,3-dioxygenase (IDO), inflammation, and interferon gamma (IFN-gamma) to anhedonic and despair-related behaviors in T. gondii-infected mice by using sucrose preference and forced-swim tests, respectively. First, we confirmed that BALB/c mice exhibited both sickness and depression-like behaviors during acute infection. Treatment of infected wild-type mice with minocycline (anti-inflammatory drug) abated sickness and anhedonic and despair-like behaviors, whereas in T. gondii-infected mice, treatment normalized kynurenine/tryptophan (Kyn/Trp) ratios in both plasma and brain tissue. Additionally, T. gondii infection failed to induce anhedonic and despair-like behaviors or increase the Kyn/Trp ratio in immunocompromised (IFN-gamma(-/-)) mice, whereas sickness behavior was observed in both immunocompetent and IFN-gamma(-/-) mice following infection. Furthermore, treatment with 1-methyl tryptophan (an IDO inhibitor) did not affect locomotor activity, attenuated clinical scores and anhedonic and despair-like behaviors, and resulted in normal Kyn/Trp ratios in T. gondii-infected wild-type mice. Although low levels of serotonin and dopamine were observed in the brain during acute and chronic infections, anhedonic and despair-like behaviors were not detected in the chronic stage of infection. Collectively, our results demonstrated that immune enhancement in response to infection with T. gondii resulted in IFN-gamma production, IDO activation, and inflammation associated with anhedonic and despair-like behaviors. |
| bibliographic_information |
en : Infection and Immunity
巻 85,
号 4,
p. e00007-17,
発行日 2017-04
|
| 出版者 |
|
|
出版者 |
American Society for Microbiology |
| item_2_source_id_9 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
00199567 |
| item_2_source_id_11 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00673732 |
| item_2_relation_14 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
info:doi/10.1128/IAI.00007-17 |
| 権利 |
|
|
権利情報 |
American Society for Microbiology |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
491 |
Supplemental Material (158.6 kB)
