WEKO3
アイテム
{"_buckets": {"deposit": "c6156e45-046f-4f7e-94d4-90a116a2821d"}, "_deposit": {"created_by": 12, "id": "1262", "owners": [12], "pid": {"revision_id": 0, "type": "depid", "value": "1262"}, "status": "published"}, "_oai": {"id": "oai:obihiro.repo.nii.ac.jp:00001262", "sets": ["5"]}, "author_link": ["2719", "2718", "176"], "item_2_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "226", "bibliographicPageStart": "219", "bibliographicVolumeNumber": "66", "bibliographic_titles": [{"bibliographic_title": "Parasitology International", "bibliographic_titleLang": "en"}]}]}, "item_2_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_2_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Neosporosis has a worldwide distribution and causes economic losses in farming, particularly by increasing the risk of abortion in cattle. This study investigated the effects of Thai piperaceae (Piper betle, P. nigrum, and P. sarmentosum) extracts on Neospora caninum infections in vitro and in vivo. In an in vitro parasite growth assay based on the green fluorescent protein (GFP) signal, P. betle was the most effective extract at inhibiting parasite growth in human foreskin fibroblast cells (IC50 of GFP-expressing N. caninum parasites, 22.1 mu g/ml). The P. betle extract, at 25 mu g per ml, inhibited parasite invasion into host cells. Furthermore, in two independent experiments, treating N. caninum-infected mice with the P. betle extract for 7 days post-infection increased their survival. In trial one, the anti-N. caninum effects of the P. betle extract reduced the mouse clinical scores for 30 days post-infection (dpi). The survival rate of the mice treated with 400 mg/kg was 100% compared with 66.6% for those treated with 100 mg/kg and the non-treated controls. In trial two, treating the infected mice with the P. betle extract increased their survival at 50 dpi. All mice in the non-treatment group died; however, the survival rates of the 400 mg/kg-treated and 100 mg/kg-treated mice were 83.3% and 33.3%, respectively. Also, a trend towards a reduced parasite burden was noted in the brains of the P. betle extract-treated mice, compared with the control mice. Therefore P. betle extract has potential as a medicinal plant for treating neosporosis. (C) 2017 Elsevier B.V. All rights reserved.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_2_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_2_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.parint.2017.01.017", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This accepted manuscript is licensed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. \u003chttp://creativecommons.org/lisenses/by-nc-nd/4.0/\u003e", "subitem_rights_language": "en"}]}, "item_2_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11112001", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13835769", "subitem_source_identifier_type": "PISSN"}]}, "item_2_subject_21": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "491", "subitem_subject_scheme": "NDC"}]}, "item_2_text_25": {"attribute_name": "文献提供者", "attribute_value_mlt": [{"subitem_text_value": "西川義文(nisikawa@obihiro.ac.jp)"}]}, "item_2_textarea_24": {"attribute_name": "作業記録", "attribute_value_mlt": [{"subitem_textarea_value": "Submitted by リポジトリ管理者 repo (repo@obihiro.ac.jp) on 2018-01-16T01:54:59Z\nNo. of bitstreams: 1\nj.parint.2017.01.017.pdf: 4110481 bytes, checksum: 0833f502649a2e3d97d703d2abc48139 (MD5)"}, {"subitem_textarea_value": "Made available in DSpace on 2018-01-16T01:54:59Z (GMT). No. of bitstreams: 1\nj.parint.2017.01.017.pdf: 4110481 bytes, checksum: 0833f502649a2e3d97d703d2abc48139 (MD5)\n Previous issue date: 2017-01"}]}, "item_2_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Leesombun, Arpron", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2718", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Boonmasawai, Sookruetai", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2719", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Nishikawa, Yoshifumi", "creatorNameLang": "en"}, {"creatorName": "西川, 義文", "creatorNameLang": "ja"}], "familyNames": [{"familyName": "Nishikawa", "familyNameLang": "en"}, {"familyName": "西川", "familyNameLang": "ja"}], "givenNames": [{"givenName": "Yoshifumi", "givenNameLang": "en"}, {"givenName": "義文", "givenNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "176", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000000186605", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000000186605"}, {"nameIdentifier": "90431395", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90431395"}, {"nameIdentifier": "read0136808", "nameIdentifierScheme": "researchmap", "nameIdentifierURI": "https://researchmap.jp/read0136808"}, {"nameIdentifier": "0000-0001-5005-6377", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-5005-6377"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-01-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "j.parint.2017.01.017.pdf", "filesize": [{"value": "4.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 4099999.9999999995, "url": {"label": "j.parint.2017.01.017.pdf", "url": "https://obihiro.repo.nii.ac.jp/record/1262/files/j.parint.2017.01.017.pdf"}, "version_id": "0e11eee5-47b0-4887-be56-39f7c8e00cfc"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Neospora caninum", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Neosporosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Piper betle", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Piper nigrum", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Piper sarmentosum", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ethanol extract", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of Thai piperaceae plant extracts on Neospora caninum infection", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effects of Thai piperaceae plant extracts on Neospora caninum infection", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "12", "path": ["5"], "permalink_uri": "https://obihiro.repo.nii.ac.jp/records/1262", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-01-16"}, "publish_date": "2018-01-16", "publish_status": "0", "recid": "1262", "relation": {}, "relation_version_is_last": true, "title": ["Effects of Thai piperaceae plant extracts on Neospora caninum infection"], "weko_shared_id": -1}
Effects of Thai piperaceae plant extracts on Neospora caninum infection
https://obihiro.repo.nii.ac.jp/records/1262
https://obihiro.repo.nii.ac.jp/records/12625d4ce1ff-099d-4a93-aa7d-ad7b484b0bac
名前 / ファイル | ライセンス | アクション |
---|---|---|
j.parint.2017.01.017.pdf (4.1 MB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2018-01-16 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Effects of Thai piperaceae plant extracts on Neospora caninum infection | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Neospora caninum | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Neosporosis | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Piper betle | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Piper nigrum | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Piper sarmentosum | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Ethanol extract | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
Leesombun, Arpron
× Leesombun, Arpron× Boonmasawai, Sookruetai× 西川, 義文
WEKO
176
|
|||||||||
抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Neosporosis has a worldwide distribution and causes economic losses in farming, particularly by increasing the risk of abortion in cattle. This study investigated the effects of Thai piperaceae (Piper betle, P. nigrum, and P. sarmentosum) extracts on Neospora caninum infections in vitro and in vivo. In an in vitro parasite growth assay based on the green fluorescent protein (GFP) signal, P. betle was the most effective extract at inhibiting parasite growth in human foreskin fibroblast cells (IC50 of GFP-expressing N. caninum parasites, 22.1 mu g/ml). The P. betle extract, at 25 mu g per ml, inhibited parasite invasion into host cells. Furthermore, in two independent experiments, treating N. caninum-infected mice with the P. betle extract for 7 days post-infection increased their survival. In trial one, the anti-N. caninum effects of the P. betle extract reduced the mouse clinical scores for 30 days post-infection (dpi). The survival rate of the mice treated with 400 mg/kg was 100% compared with 66.6% for those treated with 100 mg/kg and the non-treated controls. In trial two, treating the infected mice with the P. betle extract increased their survival at 50 dpi. All mice in the non-treatment group died; however, the survival rates of the 400 mg/kg-treated and 100 mg/kg-treated mice were 83.3% and 33.3%, respectively. Also, a trend towards a reduced parasite burden was noted in the brains of the P. betle extract-treated mice, compared with the control mice. Therefore P. betle extract has potential as a medicinal plant for treating neosporosis. (C) 2017 Elsevier B.V. All rights reserved. | |||||||||
言語 | en | |||||||||
書誌情報 |
en : Parasitology International 巻 66, 号 3, p. 219-226, 発行日 2017-01 |
|||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Elsevier | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
収録物識別子 | 13835769 | |||||||||
書誌レコードID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA11112001 | |||||||||
DOI | ||||||||||
関連タイプ | isVersionOf | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | info:doi/10.1016/j.parint.2017.01.017 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | This accepted manuscript is licensed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. <http://creativecommons.org/lisenses/by-nc-nd/4.0/> | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | AM | |||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
日本十進分類法 | ||||||||||
主題Scheme | NDC | |||||||||
主題 | 491 |