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Involvement of Host Defense Mechanisms against Toxoplasma gondii Infection in Anhedonic and Despair-Like Behaviors in Mice
https://obihiro.repo.nii.ac.jp/records/1274
https://obihiro.repo.nii.ac.jp/records/127456c60a0d-6cd1-4fd8-8f05-d99c321fc5cc
名前 / ファイル | ライセンス | アクション |
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Supplemental Material (158.6 kB)
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Manuscript (1.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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公開日 | 2017-09-15 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Involvement of Host Defense Mechanisms against Toxoplasma gondii Infection in Anhedonic and Despair-Like Behaviors in Mice | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Toxoplasma gondii | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | 1-methyl tryptophan | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | minocycline | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | interferon gamma | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | sickness behavior | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | anhedonic behavior | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | despair-like behavior | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
Mahmoud, Motamed Elsayed
× Mahmoud, Motamed Elsayed× Fereig, Ragab× 西川, 義文
WEKO
176
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Toxoplasma gondii is a pathogen relevant to psychiatric disorders. We recently showed that reactivation of chronic T. gondii infection induced depression-like behaviors in mice. Furthermore, it has been hypothesized that depression-like behaviors are mediated via a host defense mechanism against invading pathogens; proximate mechanisms of this behavioral hypothesis remain unclear. In the present study, we investigate the contribution of indoleamine 2,3-dioxygenase (IDO), inflammation, and interferon gamma (IFN-gamma) to anhedonic and despair-related behaviors in T. gondii-infected mice by using sucrose preference and forced-swim tests, respectively. First, we confirmed that BALB/c mice exhibited both sickness and depression-like behaviors during acute infection. Treatment of infected wild-type mice with minocycline (anti-inflammatory drug) abated sickness and anhedonic and despair-like behaviors, whereas in T. gondii-infected mice, treatment normalized kynurenine/tryptophan (Kyn/Trp) ratios in both plasma and brain tissue. Additionally, T. gondii infection failed to induce anhedonic and despair-like behaviors or increase the Kyn/Trp ratio in immunocompromised (IFN-gamma(-/-)) mice, whereas sickness behavior was observed in both immunocompetent and IFN-gamma(-/-) mice following infection. Furthermore, treatment with 1-methyl tryptophan (an IDO inhibitor) did not affect locomotor activity, attenuated clinical scores and anhedonic and despair-like behaviors, and resulted in normal Kyn/Trp ratios in T. gondii-infected wild-type mice. Although low levels of serotonin and dopamine were observed in the brain during acute and chronic infections, anhedonic and despair-like behaviors were not detected in the chronic stage of infection. Collectively, our results demonstrated that immune enhancement in response to infection with T. gondii resulted in IFN-gamma production, IDO activation, and inflammation associated with anhedonic and despair-like behaviors. | |||||||||
書誌情報 |
en : Infection and Immunity 巻 85, 号 4, p. e00007-17, 発行日 2017-04 |
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出版者 | ||||||||||
出版者 | American Society for Microbiology | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 00199567 | |||||||||
書誌レコードID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA00673732 | |||||||||
DOI | ||||||||||
関連タイプ | isVersionOf | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | info:doi/10.1128/IAI.00007-17 | |||||||||
権利 | ||||||||||
権利情報 | American Society for Microbiology | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | AM | |||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
日本十進分類法 | ||||||||||
主題Scheme | NDC | |||||||||
主題 | 491 |