@article{oai:obihiro.repo.nii.ac.jp:00000838,
 author = {Kawase, Osamu and Goo, Youn-Kyoung and Jujo, Hayato and Nishikawa, Yoshifumi and 西川, 義文 and Xuan, Xuenan and 玄, 学南},
 issue = {2},
 journal = {Journal of Veterinary Medical Science},
 month = {},
 note = {application/pdf, Saponin is the generic name of steroid or triterpene glycosides, and the capacities of some saponins to stimulate both Th1
immune response and production of cytotoxic T cells are useful as vaccine components against intracellular pathogens. Because saponins
have been found commonly in starfish, we assessed the potential of starfish, Asterias amurensis and Asterina pectinifera, as adjuvant
sources. Crude starfish saponins had hemolytic activities (EC50=10 to 100 μg/ml) and thin layer chromatography indicated heterogeneity
of their constituents. When starfish saponis were subcutaneously injected into mice with ovalbumin (OVA), OVA-specific IgG, especially
IgG2a instead of IgG1 was produced in mouse blood, suggesting starfish saponins stimulated Th1 type immunity and they were
potential sources of new adjuvants.},
 pages = {227--229},
 title = {Starfish, Asterias amurensis and Asterina pectinifera, as Potential Sources of Th1 Immunity-Stimulating Adjuvants},
 volume = {73},
 year = {2011}
}