{"created":"2023-05-15T15:15:13.522209+00:00","id":767,"links":{},"metadata":{"_buckets":{"deposit":"ee3eddbe-2f00-4d96-b2fb-3bbc5e3bc4b6"},"_deposit":{"created_by":12,"id":"767","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"767"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00000767","sets":["5"]},"author_link":["134","186","1637","102","64","61"],"control_number":"767","item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Early Detection of Enzootic Bovine Leukosis through Measurement of Serum Thymidine Kinase Activity","subitem_alternative_title_language":"en"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"193","bibliographicPageStart":"191","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"日本獣医師会雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of the Japan Veterinary Medical Association","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"チミジンキナーゼはDNA合成に関わる酵素の一つであり，近年牛白血病の発症マーカーとして利用できることが報告されている.今回，牛白血病ウイルス汚染農場において，本酵素の活性を測定することにより，牛白血病罹患牛の早期摘発を試みた.その結果，臨床症状は示さなかったものの，地方病性牛白血病に罹患していた10歳9カ月齢のホルスタイン種雌牛を摘発できた.牛白血病ウイルス汚染牛群における本酵素活性の測定が，地方病性牛白血病罹患牛の早期摘発に臨床上有用であることが本研究により示唆された.","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Thymidine kinase is an enzyme related to DNA　synthesis. Recently，serum thymidine kinase (STK) activity has been reported as a useful marker of bovine leukosis. In an effort to achieve earlier detection of enzootic bovine leukosis (EBL)，we measured STK activity in cows at a farm tainted by bovine leukemia virus (BLV). We found that a Holstein cow aged 10 years and 9 months without any clinical symptoms showed higher STK activity，and the cow was diagnosed as having EBL. Evaluation of STK activity in a herd contaminated with BLV is clinically useful for early detection of EBL.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医師会","subitem_publisher_language":"ja"}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本獣医師会","subitem_rights_language":"ja"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00191857","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04466454","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂本, 礼央","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大林, 哲","creatorNameLang":"ja"}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Kobayashi, Yoshiyasu","creatorNameLang":"en"},{"creatorName":"古林, 与志安","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Matsumoto, Kohtaro","creatorNameLang":"en"},{"creatorName":"松本, 高太郎","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Ishi, Mitsuo","creatorNameLang":"en"},{"creatorName":"石井, 三都夫","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Inokuma, Hisashi","creatorNameLang":"en"},{"creatorName":"猪熊, 壽","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"kessei.pdf","filesize":[{"value":"452.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kessei.pdf","url":"https://obihiro.repo.nii.ac.jp/record/767/files/kessei.pdf"},"version_id":"f10b239a-b2e4-4772-92d6-a98fa55ec8e9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"地方病性牛白血病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"早期摘発","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"血清チミジンキナーゼ活性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"early case detection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"enzootic bovine leukosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"serum thymidine kinase activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"血清チミジンキナーゼ活性の測定により早期摘発した地方病性牛白血病罹患牛の1例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血清チミジンキナーゼ活性の測定により早期摘発した地方病性牛白血病罹患牛の1例","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"12","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-06-07"},"publish_date":"2011-06-07","publish_status":"0","recid":"767","relation_version_is_last":true,"title":["血清チミジンキナーゼ活性の測定により早期摘発した地方病性牛白血病罹患牛の1例"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-04-23T01:16:35.135069+00:00"}