{"created":"2023-05-15T15:15:08.884408+00:00","id":674,"links":{},"metadata":{"_buckets":{"deposit":"29bc317d-6244-4499-8635-028540445682"},"_deposit":{"created_by":12,"id":"674","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"674"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00000674","sets":["5"]},"author_link":["318","1463","1464","1465"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-04-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"15-16","bibliographicPageEnd":"536","bibliographicPageStart":"530","bibliographicVolumeNumber":"84","bibliographic_titles":[{"bibliographic_title":"Life Sciences","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims: Bovine lactoferrin (bLf) causes anchorage-independent cell growth in PC12 cells. The present study investigated the mechanisms involved in bLf-induced anchorage-independent cell growth and survival in PC12 cells. Main methods: The number of adherent cells and suspended cells was estimated separately by using a methyl thiazol tetrazolium (MTT) assay, and the sum of both optical density (O.D.) (570 nm) values was used as a measure of the total number of cells.\nKey findings: Integrin-linked kinase (ILK) plays an important role in integrin and growth factor signaling pathways. Stable transfection of PC12 cells with a dominant negative kinase-deficient mutant of ILK (DN-ILK) inhibited bLf-induced anchorage-independent cell growth. The ILK activity in the parental cells was transiently activated after addition of bLf, whereas bLf-induced activation of ILK was blocked in DN-ILK-transfected cells. bLf also activated p38 mitogen-activated protein kinase (MAPK); however, the p38 MAPK activation was inhibited by stable DN-ILK transfection. Moreover, cell viability in the suspended cells by bLf strongly decreased after treatment with SB203580, an inhibitor of p38 MAPK. Significance: These results suggest that ILK is involved in bLf-induced anchorage-independent cell growth and viability via activation of p38 MAPK.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Elsevier"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00717011","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00243205","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishii, Toshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Uto, Tomoka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Kaori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujikawa, Ryu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"FinalRevisedbLfLifeSci2008.pdf","filesize":[{"value":"503.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FinalRevisedbLfLifeSci2008.pdf","url":"https://obihiro.repo.nii.ac.jp/record/674/files/FinalRevisedbLfLifeSci2008.pdf"},"version_id":"f71db964-902e-41e2-b3a1-fee1eeb3fd78"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bovine lactoferrin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PC12 cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Integrin-linked kinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Integrin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p38 MAPK","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell suspension","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell adhesion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell growth","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell viability","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dominant-negative mutant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anchorage-independent growth","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-10-21"},"publish_date":"2010-10-21","publish_status":"0","recid":"674","relation_version_is_last":true,"title":["Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-02-28T03:06:15.856236+00:00"}