{"created":"2023-05-15T15:15:02.640887+00:00","id":536,"links":{},"metadata":{"_buckets":{"deposit":"10f70a0d-e6df-4ae3-b8c5-892f89b9f5ce"},"_deposit":{"created_by":12,"id":"536","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"536"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00000536","sets":["5"]},"author_link":[],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Prevention of Aberrant Crypt Foci Formation by Dietary Chinese Yam (D. opposita THUNB.) in 1，2-Dimethylhydrazine-treated Mice","subitem_alternative_title_language":"en"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"275","bibliographicPageStart":"270","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"日本食品科学工学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of the Japanese Society for Food Science and Technology","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ナガイモのガンに対する機能性を探索する目的で，1,2-ジメチルヒドラジン投与マウスにおける大腸腺腫(ACF)発症に与える食餌性ナガイモ粉末の効果を検証した. ナガイモ粉末をAIN-93G標準飼料のコーンスターチ部分に100%または50%置き換えて投与したところ，大腸腺腫の発症が有意に抑制された. また，加熱および非加熱の生ナガイモ粉末ともに同様の効果が認められた. DNAマイクロアレイを用いて大腸での遺伝子の異同を調べたところ，ナガイモ投与群ではアポ卜ーシスを誘導する遺伝子群の増加が認められた. ","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"To clarify the physiological effects of dietary Chinese yam (Nagaimo) on colon cancer in vivo，the effects of dietary Nagaimo on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in the large intestine of mice were investigated. After 8 weeks of feeding raw or boiled Nagaimo and DMH administration，DMH-induced ACF formation was found to be significantly suppressed in the large intestines of all mice. DNA microarray analysis showed that levels of apoptosis-inducing gene expression in the large intestine of animals fed dietary Nagaimo were increased in comparison to those fed the control diet. The results of the present study clear1y demonstrated that DMH-induced ACF formation was inhibited in the mouse large intestine by dietary Nagaimo intake. Daily ingestion of Nagaimo may thus serve to suppress colon carcinoma in humans.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本食品科学工学会","subitem_publisher_language":"ja"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.3136/nskkk.55.270","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本食品科学工学会","subitem_rights_language":"ja"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10467499","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341027X","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木下, 幹朗","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"柚木, 恵太","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"得字, 圭彦","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"川原, 美香","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"大庭, 潔","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"弘中, 和憲","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"大西, 正男","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"jimechiru.pdf","filesize":[{"value":"575.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jimechiru.pdf","url":"https://obihiro.repo.nii.ac.jp/record/536/files/jimechiru.pdf"},"version_id":"37acd064-9a41-46be-adf8-d569a619d7db"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ナガイモ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸腺腫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸ガン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"1，2-ジメチルヒドラジン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"DNAマイクロアレイ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Chinese yam (Nagaimo)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aberrant crypt foci","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"colon cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"1, 2-dimethylhydrazine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA microarray","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"1，2-ジメチルヒドラジン投与マウスにおける大腸腺腫発症に与える食餌性ナガイモの効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"1，2-ジメチルヒドラジン投与マウスにおける大腸腺腫発症に与える食餌性ナガイモの効果","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"12","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-11-24"},"publish_date":"2010-11-24","publish_status":"0","recid":"536","relation_version_is_last":true,"title":["1，2-ジメチルヒドラジン投与マウスにおける大腸腺腫発症に与える食餌性ナガイモの効果"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-02-28T03:06:17.116555+00:00"}