{"created":"2023-05-15T15:15:01.758305+00:00","id":522,"links":{},"metadata":{"_buckets":{"deposit":"efc02d1e-85a6-4b55-abfb-622168c925a8"},"_deposit":{"created_by":12,"id":"522","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"522"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00000522","sets":["5"]},"author_link":["1182","1183","1184","1048","198","295","324"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"282","bibliographicPageStart":"273","bibliographicVolumeNumber":"116","bibliographic_titles":[{"bibliographic_title":"Experimental Parasitology","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A combination of antigenic regions of microneme proteins have been previously reported as being protective against chronic toxoplasmosis. In this work, we evaluated immune responses induced by immunizing BALB/c and C57BL/6 mice intradermally with plasmid DNA encoding the protein sequences of Toxoplasma gondii AMA1, MIC2, M2AP and BAG1. Mice immunized with the AMA1 gene developed high levels of serum IgG2a and c antibodies as well as cellular immune responses associated with IFN-γ synthesis suggesting a modulated Th1 type of response. Immunization with the AMA1 gene resulted in a partial but significant protection against the acute phase of toxoplasmosis compared to MIC2, M2AP and BAG1 genes. Therefore, the AMA1 gene appears to generate a strong specific immune response and also provides effective protection against toxoplasmosis more than the MIC2, M2AP and BAG1 genes.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Elsevier","subitem_rights_language":"en"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00641226","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00144894","subitem_source_identifier_type":"PISSN"}]},"item_2_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"649","subitem_subject_scheme":"NDC"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Dautu, George","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Munyaka, Biscah","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Carmen, Gabriella","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhang, Guohong","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Omata, Yoshitaka","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{}]}],"creatorNames":[{"creatorName":"Xuan, Xuenan","creatorNameLang":"en"},{"creatorName":"玄, 学南","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Igarashi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"igarashiM070709.pdf","filesize":[{"value":"410.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"igarashiM070709.pdf","url":"https://obihiro.repo.nii.ac.jp/record/522/files/igarashiM070709.pdf"},"version_id":"51810814-9f40-4519-bb88-2849cd5d2b09"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Toxoplasma gondii","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA","subitem_subject_scheme":"Other"},{"subitem_subject":"deoxyribonucleic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA immunization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MIC2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microneme protein-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"M2AP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MIC2 associated protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"AMA1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"apical membrane antigen-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BAG1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bradyzoite antigen-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IgG","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunoglobulin G","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BAG1 and evaluation of their immunogenic potential","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BAG1 and evaluation of their immunogenic potential","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-07-09"},"publish_date":"2007-07-09","publish_status":"0","recid":"522","relation_version_is_last":true,"title":["Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BAG1 and evaluation of their immunogenic potential"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-02-28T03:05:13.169063+00:00"}