@article{oai:obihiro.repo.nii.ac.jp:00000522,
 author = {Dautu, George and Munyaka, Biscah and Carmen, Gabriella and Zhang, Guohong and Omata, Yoshitaka and Xuan, Xuenan and 玄, 学南 and Igarashi, Makoto},
 issue = {3},
 journal = {Experimental Parasitology},
 month = {Jul},
 note = {application/pdf, A combination of antigenic regions of microneme proteins have been previously reported as being protective against chronic toxoplasmosis. In this work, we evaluated immune responses induced by immunizing BALB/c and C57BL/6 mice intradermally with plasmid DNA encoding the protein sequences of Toxoplasma gondii AMA1, MIC2, M2AP and BAG1. Mice immunized with the AMA1 gene developed high levels of serum IgG2a and c antibodies as well as cellular immune responses associated with IFN-γ synthesis suggesting a modulated Th1 type of response. Immunization with the AMA1 gene resulted in a partial but significant protection against the acute phase of toxoplasmosis compared to MIC2, M2AP and BAG1 genes. Therefore, the AMA1 gene appears to generate a strong specific immune response and also provides effective protection against toxoplasmosis more than the MIC2, M2AP and BAG1 genes.},
 pages = {273--282},
 title = {Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BAG1 and evaluation of their immunogenic potential},
 volume = {116},
 year = {2007}
}