{"created":"2023-05-15T15:18:27.806836+00:00","id":4843,"links":{},"metadata":{"_buckets":{"deposit":"c08b8623-a670-4172-8c67-23cfedb27512"},"_deposit":{"created_by":12,"id":"4843","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"4843"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00004843","sets":["5"]},"author_link":["6762","284"],"control_number":"4843","item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"144","bibliographicPageStart":"135","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Microbiology and Immunology","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aspergillus fumigatus, a ubiquitous pathogen, causes aspergillosis in humans, especially in immunodeficient patients. Azoles are frontline antifungal drugs for treating aspergillosis. The recent global emergence of azole resistance in A. fumigatus has become a serious problem worldwide. It has arisen through two routes: long-term azole medical therapy, called the patient route, and the use of azole fungicides in its habitats especially for agricultural activities, called the environmental route. Resistant strains developed through the latter route show cross-resistance to medical azoles because of the identical molecular target Cyp51A between azole compounds used for medical treatment and agricultural disease control. In azole-resistant strains arising through the environmental route, A. fumigatus is observed frequently to possess mutations in the cyp51A gene linked to tandem repeats in the promoter region such as TR34/L98H and TR46/Y121F/T289A. The results of microsatellite genotyping analyses of resistant A. fumigatus strains have suggested a transboundary spread of this microorganism in many countries. Diverse actors are involved in the global highway of transmission. Therefore, the matter must be addressed as a “One Health” issue. This review presents a background of azole resistance in A. fumigatus and introduces newly discovered difficulties generated as this pathogen spreads worldwide. © 2021 The Societies and John Wiley & Sons Australia, Ltd","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1111/1348-0421.12957","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: Rivelli Zea S.M., Toyotome T. Azole-resistant Aspergillus fumigatus as an emerging worldwide pathogen.Microbiology and Immunology. 2021;66–3, which has been published in final form at https://doi.org/10.1111/1348-0421.12957. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.","subitem_rights_language":"en"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12022389","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-5600","subitem_source_identifier_type":"PISSN"}]},"item_2_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"649","subitem_subject_scheme":"NDC"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{}]}],"creatorNames":[{"creatorName":"Rivelli, Zea S.M.","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{}]}],"creatorNames":[{"creatorName":"Toyotome, Takahito","creatorNameLang":"en"},{"creatorName":"豊留, 孝仁","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-06"}],"displaytype":"detail","filename":"toyotome_66(3)135-144_202112.pdf","filesize":[{"value":"413.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Full text","url":"https://obihiro.repo.nii.ac.jp/record/4843/files/toyotome_66(3)135-144_202112.pdf"},"version_id":"a0cf6547-f6f7-4e60-8e24-b9494a739f5b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-06"}],"displaytype":"detail","filename":"Table 1.pdf","filesize":[{"value":"186.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"table1","url":"https://obihiro.repo.nii.ac.jp/record/4843/files/Table 1.pdf"},"version_id":"aca8b649-3918-4ea1-aaf2-8726d4b433c3"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-06"}],"displaytype":"detail","filename":"Fig1.pdf","filesize":[{"value":"258.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig1","url":"https://obihiro.repo.nii.ac.jp/record/4843/files/Fig1.pdf"},"version_id":"7a3600a0-d219-419c-a64f-83e1a6a999b4"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-06"}],"displaytype":"detail","filename":"Fig2.pdf","filesize":[{"value":"242.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig2","url":"https://obihiro.repo.nii.ac.jp/record/4843/files/Fig2.pdf"},"version_id":"eaa739ad-8f1d-4cf2-9d60-bf7442a64a79"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aspergillus fumigatus; azole; drug resistance; One Health","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Azole-resistant Aspergillus fumigatus as an emerging worldwide pathogen","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Azole-resistant Aspergillus fumigatus as an emerging worldwide pathogen","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-10"},"publish_date":"2023-03-10","publish_status":"0","recid":"4843","relation_version_is_last":true,"title":["Azole-resistant Aspergillus fumigatus as an emerging worldwide pathogen"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-02-28T03:13:16.558373+00:00"}