@article{oai:obihiro.repo.nii.ac.jp:00004476,
 author = {Terkawi, Mohamad Alaa and Kuroda, Yasuhiro and 福本, 晋也 and Fukumoto, Shinya and Tanaka, Sachi and Kojima, Naoya and Nishikawa, Yoshifumi and 西川, 義文},
 issue = {1},
 journal = {Malaria Journal},
 month = {},
 note = {application/pdf, Background: The design and development of an effective malaria vaccine against the pre-erythrocytic and erythrocytic-stages of infection present a great challenge. Methods: In the present study, protective efficacy of oligomannose-coated liposome (OML)-entrapped merozoite and sporozoite antigens against Plasmodium berghei challenge infection in BALB/c mice was evaluated. Results: Subcutaneous immunization with truncated merozoite surface protein 1 entrapped with OML (OML-PbMSP1) prolonged survival, but failed to protect the mice from erythrocytic-stage infection, despite the antigen-specific antibody responses induced by the immunization regimen. In contrast, immunization with circumsporozoite protein entrapped with OML (OML-PbCSP) elicited antigen-specific humoral and cellular responses, which correlated with substantial protection against sporozoite challenge infections. Conclusions: The current results represent the use of an oligomannose-coated liposome-based vaccine against pre-erythrocytic and erythrocytic stages malaria infection. This approach may offer a new vaccination strategy against malaria infection.},
 title = {Plasmodium berghei circumsporozoite protein encapsulated in oligomannose-coated liposomes confers protection against sporozoite infection in mice},
 volume = {13},
 year = {2014}
}