@article{oai:obihiro.repo.nii.ac.jp:00004368,
 author = {三浦, 沙織 and 猪熊, 壽},
 issue = {4},
 journal = {産業動物臨床医学雑誌},
 month = {},
 note = {application/pdf, 地方病性牛白血病（EBL: Enzootic bovine leukosis）発症マーカーとしての乳酸脱水素酵素（Lactate dehydrogenase: LDH）活性値（総活性，LDHアイソザイム分画2および3活性値）測定の有用性を評価し，感度と特異性を検討した．定型EBLおよび非定型EBL症例においてLDH総活性値，アイソザイム分画2および3活性値が基準値を超えた症例の割合，すなわちEBL発症マーカーとしての感度はいずれも80％以上であった．非定型的EBLにおける感度は定型的EBLに比べると低かったが，両群のLDH総活性値，LDHアイソザイム分画2および3活性値に有意差はみられなかった．定型EBLのLDH総活性値，LDHアイソザイム分画2および3活性値は，腫瘍性疾患群，炎症性疾患群および健常群よりも有意に高値を示した．非定型EBLのLDH総活性値，LDHアイソザイム分画2および3活性値は炎症性疾患群と健常群よりも有意に高値となったが，腫瘍性疾患群とは有意差がなかった．LDH活性値の測定は，EBLと他の腫瘍の鑑別診断においては特異性に乏しかったが，炎症性疾患との鑑別には有用な検査項目になると思われた．, The usefulness of lactate dehydrogenase (LDH) activities (total activity and LDH isozymes 2 and 3) was evaluated as an onset marker of enzootic bovine leukosis (EBL), and its sensitivity and specificity were determined. The percentages of EBL cases that showed higher total, LDH-2 and LDH-3 activities than normal were 78.9% or higher. Although the sensitivity of LDH activities in atypical EBL was lower than that in typical EBL, there was no significant difference in LDH activities between the two groups. Total LDH, LDH-2 and LDH-3 activities in the typical EBL group were significantly higher than in cattle with neoplasia or inflammatory diseases and then in healthy cattle. Total LDH, LDH-2 and LDH-3 activities in cattle with atypical EBL were also higher than those with inflammatory diseases and the healthy group, but there were no significant differences between the atypical EBL and neoplasia groups. Thus, LDH activities were likely useful for differential diagnosis of EBL and inflammatory diseases but less specific for differential diagnosis of EBL and other tumors.},
 pages = {149--153},
 title = {地方病性牛白血病発症マーカーとしての乳酸脱水素酵素活性の評価},
 volume = {6},
 year = {2016}
}