@article{oai:obihiro.repo.nii.ac.jp:00004367,
 author = {前澤, 誠希 and 嘉陽, 静香 and 三浦, 沙織 and 小熊, 圭祐 and 泉對, 博 and 堀内, 雅之 and 古林, 与志安 and 古岡, 秀文 and 猪熊, 壽},
 issue = {4},
 journal = {産業動物臨床医学雑誌},
 month = {},
 note = {application/pdf, 21カ月齢黒毛和種肥育牛が下顎と耳下の腫瘤を主訴に受診した．臨床検査により体表リンパ節腫大が見られ，耳下腺リンパ節の細針吸引による細胞診で，中・大型異型リンパ球が約90%認められた．血液および血液生化学検査では著しいリンパ球増多，乳酸脱水素酵素および血清チミジンキナーゼ活性の高値が認められた．牛白血病ウイルス（Bovine leukemia virus：BLV）抗体およびBLV遺伝子を検索したところ，どちらも陽性を呈した．病理学的検査では全身のリンパ節腫大が認められ，また組織学的検査で，B細胞型の牛白血病と確定診断された．さらに，inverse-polymerase chain reaction（PCR）法により，BLVプロウイルス単クローン性組込みが確認され，本症例は地方病型牛白血病（Enzootic bovine leukosis：EBL）であると診断された．これらの結果より，EBLは3歳未満でも発症することが証明された．, A 21 month old Japanese Black fattening steer was presented with a chief complaint of mandibular and parotid masses. Physical examination revealed enlarged superficial lymph nodes. By fine needle aspiration cytology of a parotid lymph node, approximately 90% of cells were medium or large atypical lymphoid cells. Hematology and serum biochemical findings included significantly elevated lymphocytes, lactate dehydrogenase activity and thymidine kinase activity. Antibody against bovine leukemia virus （BLV） and polymerase chain reaction （PCR） for BLV provirus were both positive. Generalized lymphadenopathy was observed during necropsy, and histopathological examination confirmed bovine leukosis. Moreover, inverse PCR demonstrated monoclonal integration of BLV proviral DNA in the host genome. These findings suggest that enzootic bovine leucosis could occur in cattle less than 3 years old.},
 pages = {161--164},
 title = {牛白血病ウイルスのプロウイルス単クローン性組込みが証明された21カ月齢黒毛和種肥育牛の地方病性牛白血病},
 volume = {6},
 year = {2016}
}