@article{oai:obihiro.repo.nii.ac.jp:00004250,
 author = {Okamura, Koichi and Sasaki, Naoki and 佐々木, 直樹 and Fukunaka, Morito and Yamada, Haruo and Inokuma, Hisashi and 猪熊, 壽},
 issue = {8},
 journal = {Journal of Veterinary Medical Science},
 month = {},
 note = {application/pdf, The purpose of this study was to determine the pharmacokinetics and dose proportionality of mosapride citrate, a selective 5-HT4 agonist, after oral administration in horses. Seven healthy Thoroughbreds were dosed with distilled water and 0.5, 1.0, or 1.5 mg/kg mosapride citrate through a nasogastric tube. Serum mosapride concentrations were measured by a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method. Mosapride showed the Cmaxs of 31, 60, and 104 ng/g and AUCs of 178, 357, and 566 ng·hr/ g at doses of 0.5, 1.0, 1.5 mg/kg, respectively. The Cmaxs and AUCs increased in proportion to the dose, indicating linear pharmacokinetics of mosapride up to 1.5 mg/kg. The pharmacokinetic profiles of mosapride in horses are quite different from that in humans. The average t1/2 in horses was almost 2 fold longer than that reported in healthy adult humans. Therefore, it is thought that it is suitable to reduce the number of doses a day in horses compared to humans.},
 pages = {1023--1026},
 title = {Pharmacokinetics of the gastroprokinetic agent mosapride citrate after single oral administration in horses},
 volume = {72},
 year = {2010}
}