@article{oai:obihiro.repo.nii.ac.jp:00004219, author = {Harakawa, Shinji and 原川, 信二 and Inoue, Noboru and 井上, 昇 and Hori, Takuya and Tochio, Koji and Kariya, Tatsuya and Takahashi, Kunichito and Doge, Fuyuki and Martin, David E and Saito, Atsushi and Suzuki, Hiroshi and Nagasawa, Hideyuki}, issue = {10}, journal = {Journal of Veterinary Medical Science}, month = {}, note = {application/pdf, We previously reported that extremely low frequency electric fields (ELF-EFs) affect energy metabolism in stressed conditions. To further confirm this, the effect of exposure to ELF-EFs on the experimental ischemic rat was examined. The test was based on a comparison of rats treated with EF alone, ischemic surgery alone, the combination of EF with ischemic surgery, or no treatment (double sham). The EF condition used in this study was an alternating current of 50 Hz EF at 17 500 V/m intensity for 15 min per day. The exposure to EF in ischemic rats significantly decreased plasma levels of free fatty acids and triglycerides, compared to those of the no treatment or EF alone group. The plasma lactate levels of two ischemic groups peaked on experimental day-4 and gradually decreased until the end of the study. The changes in the lactate levels induced by ischemia did not show any difference between rats treated with ischemia alone or a combination of ischemia with an EF. Any changes in plasma levels of glucose and creatine phosphokinase activity were not influenced by EF treatment. These results indicate that the EF effect on glycolysis parameters, plasma lactate or glucose levels, does not appear in a highly stressed condition and that EF effects varied dependent on the condition of organism but ELF-EF used in this study have impact on lipid metabolism parameter in a hind-limb ischemic rat. However, further studies are needed to elucidate the association of ELF-EF with the lipid metabolism system. References (48)}, pages = {969--974}, title = {Effects of Exposure to a 50 Hz Electric Field on Plasma Levels of Lactate, Glucose, Free Fatty Acids, Triglycerides and Creatine Phosphokinase Activity in Hind-Limb Ischemic Rats}, volume = {67}, year = {2005} }