{"created":"2023-05-15T15:17:57.002897+00:00","id":4186,"links":{},"metadata":{"_buckets":{"deposit":"50e98799-842b-453d-a130-786789b88c43"},"_deposit":{"created_by":12,"id":"4186","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"4186"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00004186","sets":["5"]},"author_link":[],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"172","bibliographicPageEnd":"SJ24","bibliographicPageStart":"SJ11","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Trends in Glycoscience and Glycotechnology","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒトミルクオリゴ糖（HMO）は、母乳栄養児においてプレバイオティクス，感染防御，免疫調整，腸管成熟\nなどの生物機能を担っている。感染防御や抗炎症などの機能性にはガレクチン，セレクチン，シグレックなどのレ\nクチンと多種類のHMOとの相互作用が関わっていると予想される。一方100 種類以上含まれるHMOはHタイプ1，\nルイスa，ルイスb，ルイスx，シアリルルイスa，シアリルルイスx などの構造単位を有しているので、各種内在性\nレクチンやモノクローナル抗体、ウィルスカプシドタンパク質、細菌毒素などの糖結合特異性研究用やレクチン阻\n害剤の開発のためのツールとしての活用が期待できる。このミニレビューは、最近の構造解析結果も含む網羅的な\nHMOの構造データセットをガレクチンの糖結合特異性などの研究のための情報ソースとして提示している。またミ\nルクオリゴ糖の機能や利用についての最近のin vivoならびにヒト臨床研究例の紹介も行った。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"FCCA(Forum: Carbohydrates Coming of 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