{"created":"2023-05-15T15:17:56.961267+00:00","id":4185,"links":{},"metadata":{"_buckets":{"deposit":"e6bf06fd-7657-4831-af55-95db404f2fcd"},"_deposit":{"created_by":12,"id":"4185","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"4185"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00004185","sets":["5"]},"author_link":["291","5881","5882","5883"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"172","bibliographicPageEnd":"SE65","bibliographicPageStart":"SE51","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Trends in Glycoscience and Glycotechnology","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is now recognized that human milk oligosaccharides (HMOs) can function both as prebiotics and as decoy receptors that inhibit the attachment of pathogenic microorganisms to the colonic mucosa. They can also act as immune modulators and as colonic maturation stimulators in breast-fed infants. These functions could be mediated by biological interaction between a variety of HMOs and lectins including galectins, selectins and siglecs. There are more than 100 HMOs; they have structural units such as H type 1: Fucα1-2Galβ1-3GlcNAc, Lewis a: Galβ1-3(Fucα1-4)GlcNAc, Lewis b: Fucα1-2Galβ1-3(Fucα1-4)GlcNAc, Lewis x: Galβ1-4(Fuc α1-3)GlcNAc, sialyl Lewis a: Neu5Acα2-3Galβ1-3(Fucα1-4)GlcNAc, and sialyl Lewis x: Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAc. It can be expected that these units may be utilized as tools for studies on the sugar-binding specificities of lectins including galectins, monoclonal antibodies, virus capsid proteins and bacterial toxins. This mini-review presents the dataset of comprehensive HMO structures, including recently clarified ones, in tabular form, for its utilization in such studies, including those of carbohydrate-binding specificity of galectins. In addition, this review introduces recent in vivo and clinical studies, which may be relevant to the biological functions and future utilization of HMOs. © 2018 FCCA (Forum: Carbohydrates Coming of Age).","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"FCCA(Forum: Carbohydrates Coming of Age)","subitem_publisher_language":"en"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.4052/tigg.1734.1SE","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10995236","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09157352","subitem_source_identifier_type":"PISSN"}]},"item_2_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"489","subitem_subject_scheme":"NDC"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{}]}],"creatorNames":[{"creatorName":"Urashima, Tadasu","creatorNameLang":"en"},{"creatorName":"浦島, 匡","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Hirabayashi, Jun","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Sachiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobata, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-01-25"}],"displaytype":"detail","filename":"TIGG, HMOs and galectin, Urashima et al.pdf","filesize":[{"value":"5.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"fulltext","url":"https://obihiro.repo.nii.ac.jp/record/4185/files/TIGG, HMOs and galectin, Urashima et al.pdf"},"version_id":"32d62e42-2e61-416f-88df-ec34aef08f7a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-01-25"}],"displaytype":"detail","filename":"TIGG, Urashima et al, Table S1.pdf","filesize":[{"value":"300.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Supplementary material","url":"https://obihiro.repo.nii.ac.jp/record/4185/files/TIGG, Urashima et al, Table S1.pdf"},"version_id":"fd99029a-2fc8-4944-adae-0a128daa5c02"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Galectin binding specificity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Galectins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HMO biosynthesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HMO core structures","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HMOs","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HMOs dataset","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Human milk oligosaccharides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Milk oligosaccharides","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Human milk oligosaccharides as essential tools for basic and application studies on galectins","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human milk oligosaccharides as essential tools for basic and application studies on galectins","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-03-28"},"publish_date":"2018-03-28","publish_status":"0","recid":"4185","relation_version_is_last":true,"title":["Human milk oligosaccharides as essential tools for basic and application studies on galectins"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-02-28T02:56:20.841035+00:00"}