@article{oai:obihiro.repo.nii.ac.jp:00004172, author = {Toyotome, Takahito and 豊留, 孝仁 and Hagiwara, Daisuke and Kida, Hideyuki and Ogi, Takahiro and Watanabe, Akira and Wada, Terumi and Komatsu, Ryoichi and Kamei, Katsuhiko}, issue = {8}, journal = {Journal of Infection and Chemotherapy}, month = {}, note = {application/pdf, Recently, azole-resistant Aspergillus fumigatus containing a 34-bp or 46-bp tandem repeat in the promoter region of cyp51A combined with amino acid substitution(s) has appeared in the environment worldwide, including several Asian countries. In this study, we isolated the 34-bp tandem repeat-containing azole-resistant A. fumigatus strain OKH50 from a patient in Japan in May 2016. The patient had not been treated with medical azoles before the strain isolation, suggesting that the resistant property was acquired before infection. In addition, the patient had not traveled overseas. Our analysis of short tandem repeats of the strain indicates that the strain is strongly related to the 34-bp tandem repeat-containing isolates from European countries and Asia-Oceania countries but not to susceptible isolates from Japan, suggesting that the strain was introduced from overseas and might spread in Japan. c 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases}, pages = {579--581}, title = {First clinical isolation report of azole-resistant Aspergillus fumigatus with TR34/L98H-type mutation in Japan}, volume = {23}, year = {2017} }