{"created":"2023-05-15T15:17:02.844317+00:00","id":3063,"links":{},"metadata":{"_buckets":{"deposit":"c3ffc076-7e7b-4e4f-aa48-58a31411507e"},"_deposit":{"created_by":12,"id":"3063","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"3063"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00003063","sets":["242:243"]},"author_link":["74"],"item_6_alternative_title_1":{"attribute_name":"その他（別言語等）の研究課題名","attribute_value_mlt":[{"subitem_alternative_title":"Investigation of the selective ion transport system of mammary epithelial cells","subitem_alternative_title_language":"en"}]},"item_6_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"30581665","subitem_description_type":"Other"}]},"item_6_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"帯広畜産大学","subitem_description_type":"Other"}]},"item_6_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"乳汁分泌には乳腺分泌上皮細胞の選択的な電解質の輸送が重要であると考えられているが、どのようなイオンチャネルが機能しているかは明らかになっていない。本研究では、泌乳期のマウスから単離した乳腺分泌上皮細胞に電気生理学的手法(ホールセルパッチクランプ法)を適用し、電解質透過性を解析した。その結果、乳腺分泌上皮細胞には内向き整流性K+チャネル(Kir)が機能的に発現していることが示された。乳汁分泌におけるKirの役割についても大変興味深く、さらなる研究の進展が期待される。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"It has been suggested that the selective ion transport of mammary epithelial cells play an important role in lactation. However，active ion channels in mammary secretory cells are unknown. To reveal the mechanisms of lactation，we investigated the active ion channels in mammary secretory cells. A whole-cell patch clamp technique was applied to mammary epithelial cells (MEC) freshly isolated from mammary glands of lactating mice. In this study，we found the functional expression of inwardly rectifying potassium (Kir) channels in lactating MEC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2010年～2011年科学研究費補助金研究活動スタート支援研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_6_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"22880003","subitem_description_type":"Other"}]},"item_6_text_12":{"attribute_name":"助成元","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"科学研究費助成事業"}]},"item_6_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"22880003seika.pdf.pdf","filesize":[{"value":"317.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22880003seika.pdf.pdf","url":"https://obihiro.repo.nii.ac.jp/record/3063/files/22880003seika.pdf.pdf"},"version_id":"bd372927-6a44-45d1-a778-4d267dcd8989"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"乳腺","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"イオンチャネル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"電気生理学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"発達","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Kamikawa, Akihiro","creatorNameLang":"en"},{"creatorName":"上川, 昭博","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"乳腺上皮細胞における電解質透過性およびその調節機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"乳腺上皮細胞における電解質透過性およびその調節機構の解明","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"12","path":["243"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-07-09"},"publish_date":"2012-07-09","publish_status":"0","recid":"3063","relation_version_is_last":true,"title":["乳腺上皮細胞における電解質透過性およびその調節機構の解明"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-12-07T04:51:05.471061+00:00"}