{"created":"2023-05-15T15:17:02.595779+00:00","id":3057,"links":{},"metadata":{"_buckets":{"deposit":"f6682989-8c8e-47db-83bf-d46b4a4e1dcb"},"_deposit":{"created_by":12,"id":"3057","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"3057"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00003057","sets":["242:243"]},"author_link":["5376","5377","181"],"item_6_alternative_title_1":{"attribute_name":"その他（別言語等）の研究課題名","attribute_value_mlt":[{"subitem_alternative_title":"Development of tolerance induction method using clone pigs remodeled for expressing human ABO blood group antigen","subitem_alternative_title_language":"en"}]},"item_6_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorNames":[{"contributorName":"大西, 彰","lang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"5376","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30414890","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30414890"}]},{"contributorNames":[{"contributorName":"小林, 孝彰","lang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"5377","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70314010","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70314010"}]}]},"item_6_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"10400079","subitem_description_type":"Other"}]},"item_6_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"帯広畜産大学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は、核移植によりABO式血液型をヒト型に改変したクローン豚を作出し、それを用いてABO不適合移植の拒絶反応を制御するための新たな免疫寛容誘導法を確立する事を目的としている。その豚の作出に必用な2種類の糖転移酵素遺伝子のうちの1つを導入したクローン豚をまず作出し、次にそのブタの体細胞に2つ目の遺伝子を導入した。得られた細胞を用いた核移植によってヒトのA型を発現するブタを作出したが、生後の生育及び組織への発現に改善が求められるため、遺伝子導入法等を改変して検討している。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"This study aims to generate transgenic pigs expressing human ABO blood group antigens by using nuclear transfer method， and utilize the pigs to develop a novel tolerance induction method to control the rejection in ABO-incompatible transplantation. First， transgenic pig carrying one of the two glycosyltransferase genes to be transferred was produced，and then the second glycosyltransferase gene was transferred to the somatic cells of the transgenic pig. Using the genetically- engineered cells as a donor cell for nuclear transfer，purposed transgenic pig was produced. There has been seen some problems in the growth after birth and the expression of the purposed antigen， therefore additional studies are ongoing to solve the problems.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2009年～2011年科学研究費補助金基盤研究(B)研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_6_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"21380168","subitem_description_type":"Other"}]},"item_6_text_12":{"attribute_name":"助成元","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"科学研究費助成事業"}]},"item_6_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"21380168seika.pdf.pdf","filesize":[{"value":"376.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"21380168seika.pdf.pdf","url":"https://obihiro.repo.nii.ac.jp/record/3057/files/21380168seika.pdf.pdf"},"version_id":"e92c9343-816c-4148-ac5a-1f83ce8f0003"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"クローン家畜","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"核移植","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"移植","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"拒絶反応","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫寛容","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ABO式血液型抗原","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Ogawa, Haruko","creatorNameLang":"en"},{"creatorName":"小川, 晴子","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ABO式血液型をヒト型にリモデリングしたクローン豚を用いた免疫寛容誘導法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ABO式血液型をヒト型にリモデリングしたクローン豚を用いた免疫寛容誘導法の開発","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"12","path":["243"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-07-03"},"publish_date":"2012-07-03","publish_status":"0","recid":"3057","relation_version_is_last":true,"title":["ABO式血液型をヒト型にリモデリングしたクローン豚を用いた免疫寛容誘導法の開発"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-08-29T08:57:52.483087+00:00"}