{"created":"2023-05-15T15:17:02.468479+00:00","id":3054,"links":{},"metadata":{"_buckets":{"deposit":"5fef83fa-e21e-45b6-ba34-bb7de7a8e5eb"},"_deposit":{"created_by":12,"id":"3054","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"3054"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00003054","sets":["242:243"]},"author_link":["19","76"],"item_6_alternative_title_1":{"attribute_name":"その他（別言語等）の研究課題名","attribute_value_mlt":[{"subitem_alternative_title":"Molecular dissection of the vector-parasite relationship using Aedes-Filaria transmission system","subitem_alternative_title_language":"en"}]},"item_6_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorAffiliations":[{"contributorAffiliationNameIdentifiers":[{"contributorAffiliationNameIdentifier":"","contributorAffiliationScheme":"ISNI","contributorAffiliationURI":"http://www.isni.org/isni/"}],"contributorAffiliationNames":[{"contributorAffiliationName":"","contributorAffiliationNameLang":"ja"}]}],"contributorNames":[{"contributorName":"Kanuka, Hirotaka","lang":"en"},{"contributorName":"嘉糠, 洋陸","lang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{"nameIdentifier":"76","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50342770","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50342770"},{"nameIdentifier":"read0132674","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/read0132674"}]}]},"item_6_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"50376422","subitem_description_type":"Other"}]},"item_6_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"帯広畜産大学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヤブカ・イヌを用いたフィラリアライフサイクル実験系を用いてフィラリアと宿主の相互作用の解析により、フィラリア感染において重要な因子の解析を行った。その結果、蚊の自然免疫経路などはフィラリア感染に対して有意な機能を持たないことが明らかとなった。ベクター蚊において、他の病原微生物と比較して著しく巨大な多細胞生物であるフィラリアに対しては、既知の概念とは異なるベクター病原体相互作用が存在することが示唆された。宿主転換に際し、フィラリア側因子として脱皮関連遺伝子群が重要な働きを担うことが明らかとなった。特にcut1遺伝子は宿主転換依存的に発現していることが明らかとなり、フィラリア症制御のための新たな薬剤開発シーズとなることが期待された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"The host –parasite relationship in vector mosquito, Aedes, and Filaria parasite was analyzed. Our data indicated that the mosquito innate immune systems were not significantly affect filarial infection to mosquito vector. This result suggested the presence of completely different anti-pathogen system against filarial parasite compare to small pathogens such as protozoa, bacteria or virus. The molting related genes of filarial parasite were considered as have a key role for host transition. Especially, cut1 gene transcripts were specifically detected in host transition stage. This result indicated that cut1 could be a useful drug target for establishing novel filarial parasite infection controlling strategy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2007年度～2009年度科学研究費補助金基盤研究B(一般)研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_6_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"19380165","subitem_description_type":"Other"}]},"item_6_text_12":{"attribute_name":"助成元","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"科学研究費助成事業"}]},"item_6_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"19380165seika.pdf","filesize":[{"value":"338.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19380165seika.pdf","url":"https://obihiro.repo.nii.ac.jp/record/3054/files/19380165seika.pdf"},"version_id":"edd472ee-4d95-4596-99a6-c2928baa76d1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"イヌ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"フィラリア","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ヤブカ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"寄生虫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"福本, 晋也","creatorNameLang":"ja"},{"creatorName":"Fukumoto, Shinya","creatorNameLang":"en"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"フィラリア－ヤブカ媒介系を用いた病原体と媒介節足動物の相互作用に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"フィラリア－ヤブカ媒介系を用いた病原体と媒介節足動物の相互作用に関する研究","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"12","path":["243"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-08-30"},"publish_date":"2011-08-30","publish_status":"0","recid":"3054","relation_version_is_last":true,"title":["フィラリア－ヤブカ媒介系を用いた病原体と媒介節足動物の相互作用に関する研究"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-12-07T04:51:53.317508+00:00"}