{"created":"2023-05-15T15:17:02.169287+00:00","id":3047,"links":{},"metadata":{"_buckets":{"deposit":"58c18823-0627-4fbc-af3c-619a868e5e83"},"_deposit":{"created_by":12,"id":"3047","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"3047"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00003047","sets":["242:243"]},"author_link":["5392","76","5391","90"],"item_6_alternative_title_1":{"attribute_name":"その他（別言語等）の研究課題名","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of the roles of thioredoxin peroxidase family for adaptation to oxidative stresses in malaria parasites","subitem_alternative_title_language":"en"}]},"item_6_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorAffiliations":[{"contributorAffiliationNameIdentifiers":[{"contributorAffiliationNameIdentifier":"","contributorAffiliationScheme":"ISNI","contributorAffiliationURI":"http://www.isni.org/isni/"}],"contributorAffiliationNames":[{"contributorAffiliationName":"","contributorAffiliationNameLang":"ja"}]}],"contributorNames":[{"contributorName":"Kanuka, Hirotaka","lang":"en"},{"contributorName":"嘉糠, 洋陸","lang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{"nameIdentifier":"76","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50342770","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50342770"},{"nameIdentifier":"read0132674","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/read0132674"}]},{"contributorNames":[{"contributorName":"鳥居, 本美","lang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"5391","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20164072","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20164072"}]},{"contributorNames":[{"contributorName":"新井, 明治","lang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"5392","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30294432","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30294432"}]}]},"item_6_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"60312295","subitem_description_type":"Other"}]},"item_6_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"帯広畜産大学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"チオレドキシンペルオキシダーゼ2-Cys型Prx遺伝子を欠損するローデント（ネズミ）マラリア原虫について、これまでに観察された表現型発現のメカニズムを調べた。（１）哺乳類赤血球内でのガメートサイト（生殖母体）の分化誘導・形成阻害について：赤内期原虫タンパク質の二次元電気泳動解析から、この表現型にタンパク質リン酸化が関与することが示唆された。また（２）スポロゾイト（感染型原虫）の哺乳類宿主への感染性の低下について：マウス感染モデルを用いたRT-PCR解析から、この表現型が、スポロゾイトの障害ではなく、肝内型原虫の発育阻害に起因することが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Phenotypes observed in the rodent malaria parasite Plasmodium berghei carrying a targeted knockout of thioredoxin peroxidase, 2-Cys peroxiredoxin gene were investigated and have the following results: (1) Defect in the gametocyte (sexual stage for transition to mosquitoes) development: 2D-PAGE analysis of the blood-stage parasite proteins suggested that the defect is attributed to the protein phosphorylation; (2) Extension in the prepatent time in the sporozoite (infective stage to mammalian hosts from mosquitoes) infection: RT-PCR analysis of the experimental infections suggested that the knockout did not have any effect on the infectivity of the sporozoite, but it affects the development of the liver-stage (EEF) in the mice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2008年度～2010年度科学研究費補助金基盤研究(B)研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_6_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"20390118","subitem_description_type":"Other"}]},"item_6_text_12":{"attribute_name":"助成元","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"科学研究費助成事業"}]},"item_6_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"20390118seika.pdf","filesize":[{"value":"460.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20390118seika.pdf","url":"https://obihiro.repo.nii.ac.jp/record/3047/files/20390118seika.pdf"},"version_id":"f217340c-0c1e-4f64-8697-ffb6d5e897be"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"感染症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"マラリア","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"レドックス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子改変原虫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Kawazu, Shin-ichiro","creatorNameLang":"en"},{"creatorName":"河津, 信一郎","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"チオレドキシンペルオキシダーゼがマラリア原虫の宿主寄生適応に果たす役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"チオレドキシンペルオキシダーゼがマラリア原虫の宿主寄生適応に果たす役割の解明","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"12","path":["243"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-07-29"},"publish_date":"2011-07-29","publish_status":"0","recid":"3047","relation_version_is_last":true,"title":["チオレドキシンペルオキシダーゼがマラリア原虫の宿主寄生適応に果たす役割の解明"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-12-07T04:51:53.533451+00:00"}