{"created":"2023-05-15T15:17:01.824171+00:00","id":3039,"links":{},"metadata":{"_buckets":{"deposit":"535e8000-350d-4731-b907-5f2d5d0e67b4"},"_deposit":{"created_by":12,"id":"3039","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"3039"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00003039","sets":["242:243"]},"author_link":["312","252","5386","295"],"item_6_alternative_title_1":{"attribute_name":"その他（別言語等）の研究課題名","attribute_value_mlt":[{"subitem_alternative_title":"Proteomic analysis of the invading mechanism of Neospora caninum and development of novel preventive and treatment methods","subitem_alternative_title_language":"en"}]},"item_6_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorAffiliations":[{"contributorAffiliationNameIdentifiers":[{"contributorAffiliationScheme":"ISNI","contributorAffiliationURI":"http://www.isni.org/isni/"}],"contributorAffiliationNames":[{"contributorAffiliationNameLang":"ja"}]}],"contributorNames":[{"contributorName":"Yokoyama, Naoaki","lang":"en"},{"contributorName":"横山, 直明","lang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{"nameIdentifier":"312","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002627114","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002627114"},{"nameIdentifier":"80301802","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80301802"},{"nameIdentifier":"read0074761","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/read0074761"}]},{"contributorNames":[{"contributorName":"杉本, 千尋","lang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"252","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000014483774","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000014483774"},{"nameIdentifier":"90231373","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90231373"},{"nameIdentifier":"read0166758","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/read0166758"}]},{"contributorNames":[{"contributorName":"高島, 康弘","lang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"5386","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20333552","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20333552"}]}]},"item_6_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"10292096","subitem_description_type":"Other"}]},"item_6_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"帯広畜産大学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、プロテオミックス法によるネオスポラ原虫の全虫体タンパク質の網羅的解析を行った。MALDI-TOF-MS 解析により約600 種類の可視化されたタンパク質の中から約60 種類のタンパク質の同定に成功した。そのうちの一部は原虫の宿主細胞への吸着・侵入ならびにエネルギー代謝に関わるタンパク質であることが示唆された。これらの成果は、ネオスポラ原虫の新規ワクチン・治療薬開発に繋がるものとして期待される。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"The aims of this study were to widen our view on the global expression of protein profile of Neospora caninum parasite and to discover vaccine and drug target molecules for control of neosporosis. Approximately 600 protein spots were detected on 2-DE, and 60 proteins were identified by MALDI-TOF-MS analysis. Some of the identified proteins were predicted to be involved in the invasion of the parasite into the host cells and in parasite metabolism. Therefore, some of these proteins could be potential vaccine candidates and drug targets.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2006年度～2009年度科学研究費補助金基盤研究(B)研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_6_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"18380180","subitem_description_type":"Other"}]},"item_6_text_12":{"attribute_name":"助成元","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"科学研究費助成事業"}]},"item_6_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"18380180seika.pdf","filesize":[{"value":"223.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18380180seika.pdf","url":"https://obihiro.repo.nii.ac.jp/record/3039/files/18380180seika.pdf"},"version_id":"5381f53d-a365-4bdb-9aaf-2fcbd28b19eb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ネオスポラ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"トキソプラズマ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテオミックス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ワクチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"治療薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"MALDI-TOF-MS","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"抗原","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"酵素","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Xuan, Xuenan","creatorNameLang":"en"},{"creatorName":"玄, 学南","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"プロテオーム解析によるネオスポラ原虫感染機構の解明と新規予防・治療法開発への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プロテオーム解析によるネオスポラ原虫感染機構の解明と新規予防・治療法開発への応用","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"12","path":["243"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-12-22"},"publish_date":"2010-12-22","publish_status":"0","recid":"3039","relation_version_is_last":true,"title":["プロテオーム解析によるネオスポラ原虫感染機構の解明と新規予防・治療法開発への応用"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-08-29T08:57:17.025750+00:00"}