{"created":"2023-05-15T15:17:01.780158+00:00","id":3038,"links":{},"metadata":{"_buckets":{"deposit":"55a31c5a-0ea1-4205-ac64-4fcc44ccca04"},"_deposit":{"created_by":12,"id":"3038","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"3038"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00003038","sets":["242:243"]},"author_link":["132","151","244","248"],"item_6_alternative_title_1":{"attribute_name":"その他（別言語等）の研究課題名","attribute_value_mlt":[{"subitem_alternative_title":"Molecular physiology toward making non-regressing corpus luteum in the cow","subitem_alternative_title_language":"en"}]},"item_6_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorAffiliations":[{"contributorAffiliationNameIdentifiers":[{"contributorAffiliationNameIdentifier":"","contributorAffiliationScheme":"ISNI","contributorAffiliationURI":"http://www.isni.org/isni/"}],"contributorAffiliationNames":[{"contributorAffiliationName":"","contributorAffiliationNameLang":"ja"}]}],"contributorNames":[{"contributorName":"Shimizu, Takashi","lang":"en"},{"contributorName":"清水, 隆","lang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{"nameIdentifier":"244","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000001135036","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000001135036"},{"nameIdentifier":"90375113","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90375113"}]},{"contributorAffiliations":[{"contributorAffiliationNameIdentifiers":[{"contributorAffiliationNameIdentifier":"","contributorAffiliationScheme":"ISNI","contributorAffiliationURI":"http://www.isni.org/isni/"}],"contributorAffiliationNames":[{"contributorAffiliationName":"","contributorAffiliationNameLang":"ja"}]}],"contributorNames":[{"contributorName":"Matsui, Motozumi","lang":"en"},{"contributorName":"松井, 基純","lang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{"nameIdentifier":"132","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000001319718","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000001319718"},{"nameIdentifier":"20374762","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20374762"},{"nameIdentifier":"read0202520","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/read0202520"}]},{"contributorNames":[{"contributorName":"白砂, 孔明","lang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"248","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000019065228","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000019065228"},{"nameIdentifier":"20552780","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20552780"}]}]},"item_6_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"10192767","subitem_description_type":"Other"}]},"item_6_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"帯広畜産大学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"妊娠を成立させることは、種の保存戦略で最も基本的な事象である。哺乳動物では、妊娠成立に黄体が分泌するプロジェステロンが必須である。本研究は、黄体形成および黄体退行の分子機構を解明することで、受胎率向上への技術開発の展望を得ようとする企画である。本研究の結果から、黄体退行因子PGF2α は処置後5 分以内で黄体退行開始スイッチを入れ、黄体退行仲介因子群を発現させることが判明し、これら黄体退行仲介因子群を人為的に抑制することで、黄体退行現象を遅らせることが可能になった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Establishment of pregnancy is a basic phenomenon for the conserved strategy of species. In mammals, progesterone released from the corpus luteum has an essential key to establish pregnancy. The aim of the present study is to elucidate molecular mechanisms of development and regression of the bovine corpus luteum, and to give the new vision of developing technologies for improvement of conception rate in the cow. From the results of the present study, we clearly showed that PGF2α, a luteolytic factor, starts the luteolytic cascade within 5 minutes after intramascular injection in the cow, and PGF2α stimulates luteolytic mediators within the corpus luteum. Additionally, we showed the delay of luteolysis due to functional suppression of luteolytic mediators such as NOS, endothelin or angiotensin II.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2007年度～2009年度科学研究費補助金基盤研究(B)研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_6_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"19380154","subitem_description_type":"Other"}]},"item_6_text_12":{"attribute_name":"助成元","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"科学研究費助成事業"}]},"item_6_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"19380154seika.pdf","filesize":[{"value":"276.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19380154seika.pdf","url":"https://obihiro.repo.nii.ac.jp/record/3038/files/19380154seika.pdf"},"version_id":"047476b2-88f6-4265-bba4-c0d9e56df3ed"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"黄体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"退行","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"PGF2α","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"血管機能","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"データベース","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ウシ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Miyamoto, Akio","creatorNameLang":"en"},{"creatorName":"宮本, 明夫","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"退行しない黄体の作出に向けた分子生理学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"退行しない黄体の作出に向けた分子生理学的研究","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"12","path":["243"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-12-24"},"publish_date":"2010-12-24","publish_status":"0","recid":"3038","relation_version_is_last":true,"title":["退行しない黄体の作出に向けた分子生理学的研究"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-04-30T07:01:32.889444+00:00"}