{"created":"2023-05-15T15:17:01.690591+00:00","id":3036,"links":{},"metadata":{"_buckets":{"deposit":"b93eed4d-755c-49fd-bdc6-fb53e4332571"},"_deposit":{"created_by":12,"id":"3036","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"3036"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00003036","sets":["242:243"]},"author_link":["58","312"],"control_number":"3036","item_6_alternative_title_1":{"attribute_name":"その他(別言語等)の研究課題名","attribute_value_mlt":[{"subitem_alternative_title":"Elucidation of erythrocyte recognition and invasion by Babesia parasites","subitem_alternative_title_language":"en"}]},"item_6_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorAffiliations":[{"contributorAffiliationNameIdentifiers":[{"contributorAffiliationNameIdentifier":"","contributorAffiliationScheme":"ISNI","contributorAffiliationURI":"http://www.isni.org/isni/"}],"contributorAffiliationNames":[{"contributorAffiliationName":"","contributorAffiliationNameLang":"ja"}]}],"contributorNames":[{"contributorName":"Igarashi, Ikuo","lang":"en"},{"contributorName":"五十嵐, 郁男","lang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{"nameIdentifier":"58","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000003078567","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000003078567"},{"nameIdentifier":"80159582","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80159582"},{"nameIdentifier":"read0167555","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/read0167555"}]}]},"item_6_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"80301802","subitem_description_type":"Other"}]},"item_6_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"帯広畜産大学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"バベシア原虫による赤血球侵入時に、“シアル酸やヘパラン硫酸”が赤血球膜上の感染受容体として重要な役割を果たしていることが明らかとなった。また、いくつかの新たな原虫側リガンド候補分子が同定された。原虫リガンド分子と感染受容体の特異相互作用を介入できる糖鎖誘導体やリガンド分子に対する特異抗体の効果は、未だ治療法や予防法のないバベシア症の新規薬剤や新規ワクチンの開発に有用な知見や材料を提供している。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Sialic acids and Heparan sulfate located on erythrocytes were demonstrated to play important roles as infectious receptors in the erythrocyte invasion by Babesia parasites. In contrast, several protozoan proteins were also identified as new protozoan ligand candidates. Effects of glycoconjugates or specific antibodies on interfering the specific interactions between the protozoan ligands and erythrocyte receptors would provide us novel knowledge or materials for the development of chemotherapeutic and preventive measures against babesiosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2007年度~2009年度科学研究費補助金基盤研究(C)研究成果報告書","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_6_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"19580334","subitem_description_type":"Other"}]},"item_6_text_12":{"attribute_name":"助成元","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"科学研究費助成事業"}]},"item_6_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"19580334seika.pdf","filesize":[{"value":"185.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19580334seika.pdf","url":"https://obihiro.repo.nii.ac.jp/record/3036/files/19580334seika.pdf"},"version_id":"564466ad-e9f8-4b96-91be-45e5b62a3bd8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"寄生体生物","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Yokoyama, Naoaki","creatorNameLang":"en"},{"creatorName":"横山, 直明","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{},{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"糖鎖認識を基点としたバベシア原虫の赤血球侵入分子機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖鎖認識を基点としたバベシア原虫の赤血球侵入分子機構の解明","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"12","path":["243"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-12-24"},"publish_date":"2010-12-24","publish_status":"0","recid":"3036","relation_version_is_last":true,"title":["糖鎖認識を基点としたバベシア原虫の赤血球侵入分子機構の解明"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-12-07T04:32:11.138841+00:00"}