{"created":"2025-08-21T06:30:17.134742+00:00","id":2000417,"links":{},"metadata":{"_buckets":{"deposit":"ade41159-7c69-4d0c-8c95-e6937242bdde"},"_deposit":{"created_by":56,"id":"2000417","owners":[56],"pid":{"revision_id":0,"type":"depid","value":"2000417"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:02000417","sets":["5"]},"author_link":[],"control_number":"2000417","item_30001_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"embargoed access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_f1cf"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"155","bibliographicPageStart":"137","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Molecular Neurobiology","bibliographic_titleLang":"en"}]}]},"item_30001_creator2":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Horie, Ikuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Muroi, Yoshikage","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishii, Toshiaki","creatorNameLang":"en"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The prevalence of depression in women increases during the postpartum period. We previously reported that subchronic exposure to social stress decreased passive coping in postpartum female mice. This study aimed to investigate whether noradrenaline regulation might regulate coping styles in mice. We first determined whether a different type of stress, subchronic physical stress, decreases passive coping in postpartum females. Postpartum female, virgin female, and male mice were exposed to subchronic restraint stress (restraint stress for 4 h for 5 consecutive days). Subchronic restraint stress decreased passive coping in postpartum females but not in virgin females and males in the forced swim and tail suspension tests. We next examined the neuronal mechanism by which subchronic stress decreases passive coping in postpartum female mice. Neuronal activity and expression of noradrenergic receptors in the medial prefrontal cortex (mPFC) were analyzed using immunohistochemistry and reverse transcription-quantitative polymerase chain reaction, respectively. The mPFC was manipulated using chemogenetics, knockdown, or an α2A adrenergic receptor (AR) antagonist. Immunohistochemistry revealed that subchronic restraint stress increased glutamatergic neuron activation in the mPFC via forced swim stress and decreased α2A AR expression in postpartum females. Chemogenetic activation of glutamatergic neurons in the mPFC, knockdown of α2AAR in the mPFC, and the α2A AR receptor antagonist atipamezole treatment decreased passive coping in postpartum females. Subchronic restraint stress decreased passive coping in postpartum females by increasing glutamatergic neuron activity in the mPFC through α2A AR attenuation. The noradrenergic regulation of the mPFC may be a new target for treating postpartum depression. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.","subitem_description_type":"Abstract"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2026-07-31"}],"fileDate":[{"fileDateType":"Available","fileDateValue":"2026-07-31"}],"filename":"muroi62(1).pdf","filesize":[{"value":"5.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://obihiro.repo.nii.ac.jp/record/2000417/files/muroi62(1).pdf"},"version_id":"48a6f97d-b5f0-4532-9497-dda3be63d378"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_funder_names":[{"subitem_funder_name":"Kuribayashi Scholarship and Academic Foundation","subitem_funder_name_language":"en"}]},{"subitem_funder_names":[{"subitem_funder_name":"Takeda Science Foundation, TSF","subitem_funder_name_language":"en"}]},{"subitem_funder_names":[{"subitem_funder_name":"University of North Carolina, UNC","subitem_funder_name_language":"en"}]},{"subitem_funder_names":[{"subitem_funder_name":"Suhara Memorial Foundation","subitem_funder_name_language":"en"}]},{"subitem_funder_names":[{"subitem_funder_name":"Ministry of Education, Culture, Sports, Science and Technology, MEXT, (23H02390)","subitem_funder_name_language":"en"}]},{"subitem_funder_names":[{"subitem_funder_name":"Ministry of Education, Culture, Sports, Science and Technology, MEXT","subitem_funder_name_language":"en"}]},{"subitem_funder_names":[{"subitem_funder_name":"Akiyama Life Science Foundation, (111–076)","subitem_funder_name_language":"en"}]},{"subitem_funder_names":[{"subitem_funder_name":"Akiyama Life Science Foundation","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30001_publisher9":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_30001_relation14":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12035-024-04240-2","subitem_relation_type_select":"DOI"}}]},"item_30001_resource_type11":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_30001_rights5":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12035-024-04240-2","subitem_rights_language":"en"}]},"item_30001_rights_holder6":{"attribute_name":"権利者情報","attribute_value_mlt":[{"rightHolderNames":[{"rightHolderLanguage":"en","rightHolderName":"Springer"}]}]},"item_30001_source_identifier16":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"08937648","subitem_source_identifier_type":"PISSN"}]},"item_30001_subject7":{"attribute_name":"主題","attribute_value_mlt":[{"subitem_subject":"Medial Prefrontal Cortex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Postpartum Female","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stress Coping","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Subchronic Restraint Stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α<sub>2A</sub> Adrenergic Receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Noradrenergic Regulation of the Medial Prefrontal Cortex Mediates Stress Coping in Postpartum Female Mice","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_title":"Noradrenergic Regulation of the Medial Prefrontal Cortex Mediates Stress Coping in Postpartum Female Mice","item_type_id":"30001","owner":"56","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-08-21"},"publish_date":"2025-08-21","publish_status":"0","recid":"2000417","relation_version_is_last":true,"title":["Noradrenergic Regulation of the Medial Prefrontal Cortex Mediates Stress Coping in Postpartum Female Mice"],"weko_creator_id":"56","weko_shared_id":-1},"updated":"2025-09-05T01:03:51.481159+00:00"}