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Noradrenergic Regulation of the Medial Prefrontal Cortex Mediates Stress Coping in Postpartum Female Mice
https://obihiro.repo.nii.ac.jp/records/2000417
https://obihiro.repo.nii.ac.jp/records/20004170560f445-d982-429f-a762-43fc9928872c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
muroi62(1).pdf (5.2 MB)
Download is available from 2026/7/31.
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| アイテムタイプ | デフォルトアイテムタイプ（シンプル）(1) | |||||||||||
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| 公開日 | 2025-08-21 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Noradrenergic Regulation of the Medial Prefrontal Cortex Mediates Stress Coping in Postpartum Female Mice | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Horie, Ikuko
× Horie, Ikuko
× Muroi, Yoshikage
× Ishii, Toshiaki
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| アクセス権 | ||||||||||||
| アクセス権 | embargoed access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||||
| 権利情報 | ||||||||||||
| 権利情報 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12035-024-04240-2 | |||||||||||
| 言語 | en | |||||||||||
| 権利者情報 | ||||||||||||
| 権利者名 | Springer | |||||||||||
| 言語 | en | |||||||||||
| 主題 | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Medial Prefrontal Cortex | |||||||||||
| 主題 | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Postpartum Female | |||||||||||
| 主題 | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Stress Coping | |||||||||||
| 主題 | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Subchronic Restraint Stress | |||||||||||
| 主題 | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | α<sub>2A</sub> Adrenergic Receptor | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | The prevalence of depression in women increases during the postpartum period. We previously reported that subchronic exposure to social stress decreased passive coping in postpartum female mice. This study aimed to investigate whether noradrenaline regulation might regulate coping styles in mice. We first determined whether a different type of stress, subchronic physical stress, decreases passive coping in postpartum females. Postpartum female, virgin female, and male mice were exposed to subchronic restraint stress (restraint stress for 4 h for 5 consecutive days). Subchronic restraint stress decreased passive coping in postpartum females but not in virgin females and males in the forced swim and tail suspension tests. We next examined the neuronal mechanism by which subchronic stress decreases passive coping in postpartum female mice. Neuronal activity and expression of noradrenergic receptors in the medial prefrontal cortex (mPFC) were analyzed using immunohistochemistry and reverse transcription-quantitative polymerase chain reaction, respectively. The mPFC was manipulated using chemogenetics, knockdown, or an α2A adrenergic receptor (AR) antagonist. Immunohistochemistry revealed that subchronic restraint stress increased glutamatergic neuron activation in the mPFC via forced swim stress and decreased α2A AR expression in postpartum females. Chemogenetic activation of glutamatergic neurons in the mPFC, knockdown of α2AAR in the mPFC, and the α2A AR receptor antagonist atipamezole treatment decreased passive coping in postpartum females. Subchronic restraint stress decreased passive coping in postpartum females by increasing glutamatergic neuron activity in the mPFC through α2A AR attenuation. The noradrenergic regulation of the mPFC may be a new target for treating postpartum depression. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Springer | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子（シンプル） | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ（シンプル） | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| 関連情報 | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1007/s12035-024-04240-2 | |||||||||||
| 助成情報 | ||||||||||||
| 助成機関名 | Kuribayashi Scholarship and Academic Foundation | |||||||||||
| 言語 | en | |||||||||||
| 助成情報 | ||||||||||||
| 助成機関名 | Takeda Science Foundation, TSF | |||||||||||
| 言語 | en | |||||||||||
| 助成情報 | ||||||||||||
| 助成機関名 | University of North Carolina, UNC | |||||||||||
| 言語 | en | |||||||||||
| 助成情報 | ||||||||||||
| 助成機関名 | Suhara Memorial Foundation | |||||||||||
| 言語 | en | |||||||||||
| 助成情報 | ||||||||||||
| 助成機関名 | Ministry of Education, Culture, Sports, Science and Technology, MEXT, (23H02390) | |||||||||||
| 言語 | en | |||||||||||
| 助成情報 | ||||||||||||
| 助成機関名 | Ministry of Education, Culture, Sports, Science and Technology, MEXT | |||||||||||
| 言語 | en | |||||||||||
| 助成情報 | ||||||||||||
| 助成機関名 | Akiyama Life Science Foundation, (111–076) | |||||||||||
| 言語 | en | |||||||||||
| 助成情報 | ||||||||||||
| 助成機関名 | Akiyama Life Science Foundation | |||||||||||
| 言語 | en | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 08937648 | |||||||||||
| 書誌情報 |
en : Molecular Neurobiology 巻 62, 号 1, p. 137-155, 発行日 2025-07 |
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