@article{oai:obihiro.repo.nii.ac.jp:00001502,
 author = {Takashima, Yasuhiro and Xuan, Xuenan and 玄, 学南 and Shirafuji, Hiroaki and Zhang, Guohong and Otsuka, Haruki},
 issue = {1-2},
 journal = {The journal of protozoology research},
 month = {Apr},
 note = {application/pdf, To develop DNA vaccines against Cryptosporidiosis, a plasmid coding an immunodominant protein of Cryptosporidium parvum sporozoite, p23 (pCX-p23) and another plasmid coding a fusion protein containing whole the p23 and the Fc portion of mouse immunogloblin G1 (pCX-p23Fc). Vaccination of BALB/c mice with the plasmid, pCX-p23 and pCX-p23Fc induced the production of antibodies against p23. Although both of splenocytes of mice immunized with the plasmids pCX-p23 and pCX-p23Fc expressed interleukin-4 and interferon-8, after the in vitro stimulation by p23 antigen, the interferon-8 expression level of pCX-p23Fc immunized mice was much higher than that of pCX-p23 immunized mice. These results suggest a possibility  of the plasmid pCX-p23Fc as a DNA vaccine candidate against cryptosporidiosis.},
 pages = {14--19},
 title = {DNA vaccine coding a p23 protein of Cryptosporidium parvum fused with Fc portion of immunogloblin G induces higher level of interferon-γ expression in mice},
 volume = {15},
 year = {2005}
}