{"created":"2023-05-15T15:15:49.039289+00:00","id":1497,"links":{},"metadata":{"_buckets":{"deposit":"701c7a4a-43f3-4823-9fe9-f36c619c4bb7"},"_deposit":{"created_by":12,"id":"1497","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"1497"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00001497","sets":["12:27"]},"author_link":["3223","3224","3225","282","238","3226","352"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"47","bibliographicPageStart":"41","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"The journal of protozoology research","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Interleukin-12 (IL-12) is one of the most important factors for the host’s protective immune response against protozoan infection. To evaluate the effect of bioactive form of IL-12(IL-12p70), expression of IFN-AmRNA and IL-4 mRNA in splenic CD4 positive T cells, anti-parasite delayed type hypersensitivity (DTH), and serum and splenic IL-12p70 concentration were examined in Babesia microti and B. rodhaini infected mice. The expression of IFN-AmRNA as a marker of Th1 cell differentiation was detected in splenic CD4 positive T cells in B. microti infected mice. Activation of DTH response as a marker of cell-mediated immune response was also observed from 2 days after the infection with B. microti, while no response was detected in B. rodhaini infected mice. Serum IL-12p70 was not detected in both B. microti and B. rodhaini infected mice, however, splenic IL-12p70 concentration increased significantly in B. microti infected mice with peaks at 30 hrs and 4 days after the infection. From these results, splenic IL-12p70 increased at 30 hrs after the B. microti infection was considered to closely relate with Th1 cell differentiation followed by cell-mediated immune response in mice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"National Research Center for Protozoan Diseases","subitem_publisher_language":"en"}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"National Research Center for Protozoan Diseases","subitem_rights_language":"en"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10824856","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09174427","subitem_source_identifier_type":"PISSN"}]},"item_2_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"649","subitem_subject_scheme":"NDC"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohmori, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamahara, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Thi, Pham Ngoc","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomihari, Mizuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Shimada, Terumasa","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Matsuki, Naoaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ono, Kenichiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"Prot.Vol15-(6).pdf","filesize":[{"value":"140.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Prot.Vol15-(6).pdf","url":"https://obihiro.repo.nii.ac.jp/record/1497/files/Prot.Vol15-(6).pdf"},"version_id":"be21775e-766b-4f9b-a0f2-02423ebde0df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Babesia microti","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Babesia rodhaini","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell-mediated immunity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"early phase of infection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-12p70","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Th1 cell differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Changes of splenic interleukin-12p70 concentration in mice infected with Babesia microti and Babesia rodhaini","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Changes of splenic interleukin-12p70 concentration in mice infected with Babesia microti and Babesia rodhaini","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["27"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-12-20"},"publish_date":"2006-12-20","publish_status":"0","recid":"1497","relation_version_is_last":true,"title":["Changes of splenic interleukin-12p70 concentration in mice infected with Babesia microti and Babesia rodhaini"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-08-23T06:02:16.171928+00:00"}