@article{oai:obihiro.repo.nii.ac.jp:00001485,
 author = {Kuboki, Noritaka and Tiwananthagorn, Weerawan and Takagi, Hideaki and Nakayama, Tomoko and Xuan, Xuenan and 玄, 学南 and Inoue, Noboru and 井上, 昇 and Igarashi, Ikuo and 五十嵐, 郁男 and Tsujimura, Kunio and Ikehara, Yuzuru and Kojima, Naoya and Yokoyama, Naoaki and 横山, 直明},
 issue = {1},
 journal = {The journal of protozoology research},
 month = {Jun},
 note = {application/pdf, The oligomannose-coated liposome (OML) vaccine is known to induce cellular immunity specific for the encapsulated antigen in immunized mice. In the present study, we preliminarily evaluated the effect of the OML vaccine encapsulating the soluble protozoan lysate of Toxoplasma gondii, Trypanosoma brucei gambiense, or Babesia rodhaini on the corresponding protozoan infections in mice. After the challenge of T. gondii, the OML vaccine group avoided the high mortality resulting from acute infection that was dominantly observed in other control groups. During the infectious course, the development of the T. gondii-specific antibody, which is an indicator of humoral immunity, was constantly controlled at a lower level in the surviving mice of the OML vaccine group than in other lethally affected mice. On the other hand, other OML vaccines targeting for T. b. gambiense and B. rodhaini did not show any effect on these lethal infections in mice. The present preliminary study suggests that OML is a novel vaccine tool, at least for the control of acute toxoplasmosis.},
 pages = {9--15},
 title = {Preliminary evaluation of oligomannose-coated liposome vaccines against lethal protozoan infections in mice},
 volume = {17},
 year = {2007}
}