{"created":"2023-05-15T15:15:33.318834+00:00","id":1173,"links":{},"metadata":{"_buckets":{"deposit":"abc5944c-b4da-4715-b07a-0b1f0e3a7667"},"_deposit":{"created_by":12,"id":"1173","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"1173"},"status":"published"},"_oai":{"id":"oai:obihiro.repo.nii.ac.jp:00001173","sets":["5"]},"author_link":[],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Causative Agents of Aspergillosis Including Cryptic Aspergillus Species and A. fumigatus","subitem_alternative_title_language":"en"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"J154","bibliographicPageStart":"J149","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Medical Mycology Journal","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アスペルギルス症は深在性真菌感染症の重要な位置を占めている．アスペルギルス症の原因真菌はAspergillus fumigatusが最も重要であるが，そのほかにもAspergillus flavusやAspergillus niger, Aspergillus terreusなども重要な原因菌種である．また，近年になって隠蔽種と呼ばれる各Aspergillus sectionの代表的な種に非常によく似た菌種の存在が認識され，一部のアスペルギルス症の原因となっていることも分かってきた．最近の研究で，それらの菌種間では抗真菌薬に対する感受性や二次代謝産物の産生プロファイル (エクソメタボローム) が異なることも明らかとなってきた．一方，治療中のA. fumigatusアゾール耐性化や近年の欧州を中心とした環境中アゾール耐性A. fumigatusの出現も報告され，これら菌種を正確に同定し，加えて感受性を評価することの重要性が高まってきている．本総説ではA. fumigatusを含めたアスペルギルス症原因菌種，特に隠蔽種について触れ，エクソメタボローム解析を利用した同定の可能性を述べる．加えて，A. fumigatusアゾール系抗真菌薬耐性について最近の報告を交えて概説したい．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本医真菌学会","subitem_publisher_language":"ja"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.3314/mmj.16.005","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本医真菌学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12518136","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21856486","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"豊留, 孝仁","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-30"}],"displaytype":"detail","filename":"toyotome57(4),J149-J154,2016.pdf","filesize":[{"value":"909.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"toyotome57(4),J149-J154,2016.pdf","url":"https://obihiro.repo.nii.ac.jp/record/1173/files/toyotome57(4),J149-J154,2016.pdf"},"version_id":"719d539a-5eab-4676-a9d2-45afed6d5009"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"aspergillosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aspergillus spp.","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"azole resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cryptic species","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"secondary metabolites","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"原因真菌から見たアスペルギルス症","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"原因真菌から見たアスペルギルス症","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"12","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-02-28"},"publish_date":"2017-02-28","publish_status":"0","recid":"1173","relation_version_is_last":true,"title":["原因真菌から見たアスペルギルス症"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-03-11T02:04:24.698199+00:00"}