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Ouabain exacerbates botulinum neurotoxin-induced muscle paralysis via progression of muscle atrophy in mice
https://obihiro.repo.nii.ac.jp/records/728
https://obihiro.repo.nii.ac.jp/records/7286c7bb4f3-a4d1-4c27-a58c-698c34137b72
名前 / ファイル | ライセンス | アクション |
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Ouabain.pdf (5.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2012-02-28 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Ouabain exacerbates botulinum neurotoxin-induced muscle paralysis via progression of muscle atrophy in mice | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Ouabain | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Botulinum neurotoxin | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Muscle atrophy | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | MAFbx | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | MuRF-1 | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Fujikawa, Ryu
× Fujikawa, Ryu× Muroi, Yoshikage× Unno, Toshihiro× Ishii, Toshiaki
WEKO
318
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Botulinum neurotoxin serotype A (BoNT/A) inhibits acetylcholine release at the neuromuscular junction in isolated muscles, and ouabain can partially block its effect. However, it is not clear whether ouabain attenuates BoNT/A-induced neuromuscular paralysis in vivo. In this work, we investigated the effects of ouabain on BoNT/A-induced neuromuscular paralysis in mice. Ouabain was administered to mice intraperitoneally immediately after a single injection of BoNT/A into skeletal muscle. The effects of ouabain on BoNT/A-induced muscle paralysis were assessed by quantitative monitoring of muscle tension and digit abduction via the digit abduction scoring (DAS) assay. A single administration of ouabain significantly prolonged BoNT/A-induced neuromuscular paralysis. Moreover, consecutive daily injection of ouabain exacerbated BoNT/A-induced neuromuscular paralysis, and led to a significant decrease in both twitch and tetanic forces as assayed in isolated BoNT/A-injected muscles. We next looked at the effects of ouabain on BoNT/A-induced muscle atrophy. Administration of ouabain led to a decrease in the myofibrillar cross-sectional area (CSAs) by 14 post-BoNT/A injection. In addition, repeated administration of ouabain increased mRNA expression levels of ubiquitin ligases, which are markers of muscle atrophy, in BoNT/A-injected muscle. These results suggest that ouabain exacerbates BoNT/A-induced neuromuscular paralysis via a marked progression of BoNT/A-induced muscle atrophy. | |||||||
言語 | en | |||||||
書誌情報 |
en : Journal of Toxicological Sciences 巻 35, 号 6, p. 795-805, 発行日 2010 |
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出版者 | ||||||||
言語 | en | |||||||
出版者 | Japanese Society of Toxicology | |||||||
ISSN | ||||||||
収録物識別子タイプ | PISSN | |||||||
収録物識別子 | 03881350 | |||||||
書誌レコードID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AN00002808 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | info:doi/10.2131/jts.35.795 | |||||||
権利 | ||||||||
言語 | en | |||||||
権利情報 | Japanese Society of Toxicology | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |