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Role of Adherent Spleen Cells in the Induction of Cytotoxic Activity by Toxoplasma Lysate Antigen
名前 / ファイル | ライセンス | アクション |
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miyahara54(4), 629-635, 1992.pdf (909.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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公開日 | 2015-04-24 | |||||||||||||
タイトル | ||||||||||||||
言語 | en | |||||||||||||
タイトル | Role of Adherent Spleen Cells in the Induction of Cytotoxic Activity by Toxoplasma Lysate Antigen | |||||||||||||
言語 | ||||||||||||||
言語 | eng | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | adherent cell | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | cytotoxic activity | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | macrophage | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | spleen cell | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Toxoplasma lysate antigen | |||||||||||||
資源タイプ | ||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
資源タイプ | journal article | |||||||||||||
その他(別言語等)のタイトル | ||||||||||||||
その他のタイトル | トキソブラズマ溶解抗原(TLA)によって誘導される細胞障害性における脾臓の付着性細胞の役割 | |||||||||||||
言語 | ja | |||||||||||||
著者 |
Miyahara, Kazuro
× Miyahara, Kazuro
WEKO
147
× Tose, Shinichi× Sakurai, Haruhisa× 五十嵐, 郁男
WEKO
58
× Saito, Atsushi
WEKO
210
× 広瀬, 恒夫× Suzuki, Naoyoshi |
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抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | In order to identify mechanisms responsible for the anti-tumor effects of Toxoplasma lysate antigen (TLA), we used an in vitro 51Cr release assay to study the functional properties of plastic-adherent cells during induction of splenic cytotoxic activity by TLA. Cytotoxic activity of non-adherent cells was measured in all experiments after a 6 days incubation. Induction of cytotoxic non-adherent cells by TLA required the presence of plastic-adherent spleen cells. In contrast, rhIL-2 alone was able to induce transformation of cytotoxic non-adherent cells from non-adherent spleen cells. Contact between adherent and non-adherent spleen cells was necessary for successful induction of cytotoxic non-adherent cells by TLA. Treatment of spleen cells with anti-macrophage serum prevented induction of cytotoxic activity by TLA. Biologically active IL-2 was not detected in culture supernatants of spleen cells exposed to TLA. These findings suggest that contact between TLA-sensitized non-adherent cells and macrophages is necessary for induction of cytotoxic cells in the presence of TLA. This contact, however, is not necessary for generation of IL-2-induced killer cells. | |||||||||||||
言語 | en | |||||||||||||
書誌情報 |
en : Journal of Veterinary Medical Science 巻 54, 号 4, p. 629-635, 発行日 1992 |
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出版者 | ||||||||||||||
言語 | en | |||||||||||||
出版者 | Japanese Society of Veterinary Science | |||||||||||||
ISSN | ||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||
収録物識別子 | 09167250 | |||||||||||||
書誌レコードID | ||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||
収録物識別子 | AA10796138 | |||||||||||||
DOI | ||||||||||||||
関連タイプ | isIdenticalTo | |||||||||||||
識別子タイプ | DOI | |||||||||||||
関連識別子 | info:doi/10.1292/jvms.54.629 | |||||||||||||
権利 | ||||||||||||||
言語 | en | |||||||||||||
権利情報 | Japanese Society of Veterinary Science | |||||||||||||
フォーマット | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | application/pdf | |||||||||||||
著者版フラグ | ||||||||||||||
出版タイプ | VoR | |||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |