WEKO3
アイテム
{"_buckets": {"deposit": "40a3cec4-683f-40b5-b952-2a95c8468023"}, "_deposit": {"created_by": 12, "id": "527", "owners": [12], "pid": {"revision_id": 0, "type": "depid", "value": "527"}, "status": "published"}, "_oai": {"id": "oai:obihiro.repo.nii.ac.jp:00000527", "sets": ["5"]}, "author_link": ["58", "1194", "1192", "1193", "312"], "item_2_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "217", "bibliographicPageStart": "214", "bibliographicVolumeNumber": "117", "bibliographic_titles": [{"bibliographic_title": "Experimental Parasitology", "bibliographic_titleLang": "en"}]}]}, "item_2_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_2_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In the present study, we examined the effects of four kinds of cysteine protease inhibitors (E64, E64d, leupeptin, and ALLN) on the in vitro asexual growth of Babesia bovis. Of these, only the lipophilic inhibitors, E64d and ALLN, were found to effectively inhibit the growth of B. bovis. In further experiments, E64d, but not ALLN, significantly suppressed the parasite’s invasion of host erythrocytes, while both chemicals, especially ALLN, inhibited the parasite’s replication within the infected erythrocytes. These data suggested the presence of cysteine protease(s) derived from B. bovis, in which the protease(s) would play important roles in the erythrocyte invasion and/or replication processes of the parasite.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_2_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_2_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.exppara.2007.04.009", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Elsevier", "subitem_rights_language": "en"}]}, "item_2_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00641226", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00144894", "subitem_source_identifier_type": "PISSN"}]}, "item_2_subject_21": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "649", "subitem_subject_scheme": "NDC"}]}, "item_2_textarea_24": {"attribute_name": "作業記録", "attribute_value_mlt": [{"subitem_textarea_value": "Submitted by リポジトリ管理者 repo (repo@obihiro.ac.jp) on 2007-07-13T07:43:31Z\nNo. of bitstreams: 1\nyokoyamaN070713-2.pdf: 113601 bytes, checksum: f8032febf5bd0b0ba7fda819ab4c2866 (MD5)"}, {"subitem_textarea_value": "Made available in DSpace on 2007-07-13T07:43:31Z (GMT). No. of bitstreams: 1\nyokoyamaN070713-2.pdf: 113601 bytes, checksum: f8032febf5bd0b0ba7fda819ab4c2866 (MD5)\n Previous issue date: 2007-05"}]}, "item_2_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Okubo, Kazuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1192", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Yokoyama, Naoaki", "creatorNameLang": "en"}, {"creatorName": "横山, 直明", "creatorNameLang": "ja"}], "familyNames": [{"familyName": "Yokoyama", "familyNameLang": "en"}, {"familyName": "横山", "familyNameLang": "ja"}], "givenNames": [{"givenName": "Naoaki", "givenNameLang": "en"}, {"givenName": "直明", "givenNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "312", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000002627114", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000002627114"}, {"nameIdentifier": "80301802", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80301802"}, {"nameIdentifier": "read0074761", "nameIdentifierScheme": "researchmap", "nameIdentifierURI": "https://researchmap.jp/read0074761"}]}, {"creatorNames": [{"creatorName": "Govind, Yadav", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1193", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Alhassan, Andy", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1194", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Igarashi, Ikuo", "creatorNameLang": "en"}, {"creatorName": "五十嵐, 郁男", "creatorNameLang": "ja"}], "familyNames": [{"familyName": "Igarashi", "familyNameLang": "en"}, {"familyName": "五十嵐", "familyNameLang": "ja"}], "givenNames": [{"givenName": "Ikuo", "givenNameLang": "en"}, {"givenName": "郁男", "givenNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "58", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000003078567", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000003078567"}, {"nameIdentifier": "80159582", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80159582"}, {"nameIdentifier": "read0167555", "nameIdentifierScheme": "researchmap", "nameIdentifierURI": "https://researchmap.jp/read0167555"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-01-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "yokoyamaN070713-2.pdf", "filesize": [{"value": "113.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 113600.0, "url": {"label": "yokoyamaN070713-2.pdf", "url": "https://obihiro.repo.nii.ac.jp/record/527/files/yokoyamaN070713-2.pdf"}, "version_id": "03b5d970-f00d-420f-8c8f-9708ec5ec315"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Babesia bovis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cysteine protease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Inhibitor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Invasion", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Replication", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Babesia bovis: Effects of cysteine protease inhibitors on in vitro growth", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Babesia bovis: Effects of cysteine protease inhibitors on in vitro growth", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "12", "path": ["5"], "permalink_uri": "https://obihiro.repo.nii.ac.jp/records/527", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-07-13"}, "publish_date": "2007-07-13", "publish_status": "0", "recid": "527", "relation": {}, "relation_version_is_last": true, "title": ["Babesia bovis: Effects of cysteine protease inhibitors on in vitro growth"], "weko_shared_id": -1}
Babesia bovis: Effects of cysteine protease inhibitors on in vitro growth
https://obihiro.repo.nii.ac.jp/records/527
https://obihiro.repo.nii.ac.jp/records/527bc517202-2083-45d6-a1a1-490c2dad5475
名前 / ファイル | ライセンス | アクション |
---|---|---|
yokoyamaN070713-2.pdf (113.6 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2007-07-13 | |||||||||||||
タイトル | ||||||||||||||
言語 | en | |||||||||||||
タイトル | Babesia bovis: Effects of cysteine protease inhibitors on in vitro growth | |||||||||||||
言語 | ||||||||||||||
言語 | eng | |||||||||||||
キーワード | ||||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Babesia bovis | |||||||||||||
キーワード | ||||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Cysteine protease | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Inhibitor | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Invasion | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Replication | |||||||||||||
資源タイプ | ||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
資源タイプ | journal article | |||||||||||||
著者 |
Okubo, Kazuhiro
× Okubo, Kazuhiro× 横山, 直明
WEKO
312
× Govind, Yadav× Alhassan, Andy× 五十嵐, 郁男
WEKO
58
|
|||||||||||||
抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | In the present study, we examined the effects of four kinds of cysteine protease inhibitors (E64, E64d, leupeptin, and ALLN) on the in vitro asexual growth of Babesia bovis. Of these, only the lipophilic inhibitors, E64d and ALLN, were found to effectively inhibit the growth of B. bovis. In further experiments, E64d, but not ALLN, significantly suppressed the parasite’s invasion of host erythrocytes, while both chemicals, especially ALLN, inhibited the parasite’s replication within the infected erythrocytes. These data suggested the presence of cysteine protease(s) derived from B. bovis, in which the protease(s) would play important roles in the erythrocyte invasion and/or replication processes of the parasite. | |||||||||||||
言語 | en | |||||||||||||
書誌情報 |
en : Experimental Parasitology 巻 117, 号 2, p. 214-217, 発行日 2007-10 |
|||||||||||||
出版者 | ||||||||||||||
言語 | en | |||||||||||||
出版者 | Elsevier | |||||||||||||
ISSN | ||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||
収録物識別子 | 00144894 | |||||||||||||
書誌レコードID | ||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||
収録物識別子 | AA00641226 | |||||||||||||
DOI | ||||||||||||||
関連タイプ | isIdenticalTo | |||||||||||||
識別子タイプ | DOI | |||||||||||||
関連識別子 | info:doi/10.1016/j.exppara.2007.04.009 | |||||||||||||
権利 | ||||||||||||||
言語 | en | |||||||||||||
権利情報 | Elsevier | |||||||||||||
フォーマット | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | application/pdf | |||||||||||||
著者版フラグ | ||||||||||||||
出版タイプ | VoR | |||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
日本十進分類法 | ||||||||||||||
主題Scheme | NDC | |||||||||||||
主題 | 649 |