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Babesia gibsoni ribosomal phosphoprotein P0 induces cross-protective immunity against B-microti infection in mice
名前 / ファイル | ライセンス | アクション |
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gen070711-4.pdf (247.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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公開日 | 2007-07-11 | |||||||||||||||||||
タイトル | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
タイトル | Babesia gibsoni ribosomal phosphoprotein P0 induces cross-protective immunity against B-microti infection in mice | |||||||||||||||||||
言語 | ||||||||||||||||||||
言語 | eng | |||||||||||||||||||
キーワード | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | B. gibsoni | |||||||||||||||||||
キーワード | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | B. microti | |||||||||||||||||||
キーワード | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | ribosomal phosphoprotein P0 | |||||||||||||||||||
キーワード | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | cross-reactive antigen | |||||||||||||||||||
資源タイプ | ||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
資源タイプ | journal article | |||||||||||||||||||
著者 |
Terkawi, M. Alaa
× Terkawi, M. Alaa
WEKO
359
× Jia, Honglin× Zhou, Jinlin× Lee, Eung-goo× 五十嵐, 郁男
WEKO
58
× Fujisaki, Kozo× 西川, 義文
WEKO
176
× 玄, 学南
WEKO
295
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抄録 | ||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||
内容記述 | Babesia gibsoni ribosomal phosphoprotein PO (BgP0) was identified as an immunodominant cross-reactive antigen with B. microti. The BgPO gene is a single copy with a predicted open reading frame of 942 bp and 314 amino acids. The BgP0 was expressed as a glutathione S-transferase fusion protein in Escherichia coli. The serum raised in mice with the recombinant BgPO showed a specific band with a 34-kDa molecular mass in the extracts of B. gibsoni and B. microti merozoites. Furthermore, the intraperitoneal (i.p.) immunization of rBgP0 and Freund's adjuvant induced strong Immoral response consisting of mixed immunoglobulins IgG1 and IgG2a in BALB/c mice. Following the challenge with B. microti, these mice delayed the onset of parasites and significantly reduced the peripheral parasitemia. On the other hand, passive-transfer of purified anti-BgPO IgG into SCID mice showed partial protection against B. microti challenge infection. It was only effective in restricting the initial parasitemia but not later during its progress. Taken together, the immunological response elicited by rBgP0 protected the mice against B. microti challenge infection. These data suggest that BgP0 is a potentially universal vaccine candidate for both B. gibsoni and B. microti infections. (c) 2006 Elsevier Ltd. All rights reserved. | |||||||||||||||||||
言語 | en | |||||||||||||||||||
書誌情報 |
en : Vaccine 巻 25, 号 11, p. 2027-2035, 発行日 2007-03-01 |
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出版者 | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
出版者 | Elsevier | |||||||||||||||||||
ISSN | ||||||||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||||||||
収録物識別子 | 0264410X | |||||||||||||||||||
書誌レコードID | ||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||
収録物識別子 | AA10491877 | |||||||||||||||||||
権利 | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
権利情報 | Elsevier | |||||||||||||||||||
フォーマット | ||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||
内容記述 | application/pdf | |||||||||||||||||||
著者版フラグ | ||||||||||||||||||||
出版タイプ | VoR | |||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
日本十進分類法 | ||||||||||||||||||||
主題Scheme | NDC | |||||||||||||||||||
主題 | 491 |