WEKO3
アイテム
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Species-specificity of a Panel of Prion Protein Antibodies for the Immunohistochemical Study of Animal and Human Prion Diseases
https://obihiro.repo.nii.ac.jp/records/498
https://obihiro.repo.nii.ac.jp/records/498a1b837ba-140c-4804-9fd2-218a0853ae6b
名前 / ファイル | ライセンス | アクション |
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fu070730.pdf (429.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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公開日 | 2007-07-30 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Species-specificity of a Panel of Prion Protein Antibodies for the Immunohistochemical Study of Animal and Human Prion Diseases | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | BSE | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | cattle | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | CJD | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | GSS disease | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | man | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | mouse | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | scrapie | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | sheep | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
古岡, 秀文
× 古岡, 秀文
WEKO
23
× Yabuzoe, Atushi× Horiuchi, Motohiro× Tagawa, Yuichi× Yokoyama, Takashi× Yamakawa, Yoshio× Shinagawa, Morikazu× Sata, Tetsutaro |
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Monoclonal antibodies to the prion protein (PrP) have been of critical importance in the neuropathological characterization of PrP-related disease in men and animals. To determine the influence of species-specific amino-acid substitutions recognized by monoclonal antibodies, and to investigate the immunohistochemical reactivity of the latter, analyses were carried out on brain sections of cattle with bovine spongiform encephalopathy, sheep with scrapie, mice infected with scrapie, and human beings with Creutzfeldt-Jakob disease (CJD) or Gerstmann-Sträussler-Sheinker disease (GSS). Immunoreactivity varied between the antibodies, probably as the result of differences in the amino-acid sequence of the prion protein in the various species. Some monoclonal antibodies against mouse recombinant PrP gave strong signals with bovine, ovine and human PrPSc, in addition to murine PrPSc, even though the amino-acid sequences determined by the antibody epitope are not fully identical with the amino-acid sequences proper to the species. On the other hand, in certain regions of the PrP sequence, when the species-specificity of the antibodies is defined by one amino-acid substitution, the antibodies revealed no reactivity with other animal species. In the region corresponding to positions 134–159 of murine PrP, immunohistochemical reactivity or species-specificity recognized by the antibodies may be determined by one amino acid corresponding to position 144 of murine PrP. Not all epitopes recognized by a monoclonal antibody play an important role in antigen–antibody reactions in immunohistochemistry. The presence of the core epitope is therefore vital in understanding antibody binding ability. | |||||||||
言語 | en | |||||||||
書誌情報 |
en : Journal of Comparative Pathology 巻 136, 号 1, p. 9-17, 発行日 2007-01 |
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出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Elsevier | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
収録物識別子 | 00219975 | |||||||||
書誌レコードID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA0069594X | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | Elsevier | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
日本十進分類法 | ||||||||||
主題Scheme | NDC | |||||||||
主題 | 649.5 |