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Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice
https://obihiro.repo.nii.ac.jp/records/4724
https://obihiro.repo.nii.ac.jp/records/472477326ce3-213e-4e5c-a372-2c22645f28c7
名前 / ファイル | ライセンス | アクション |
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fulltext (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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公開日 | 2021-02-15 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
原川, 信二
× 原川, 信二
WEKO
33
× Nedachi, Takaki× Suzuki, Hiroshi |
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Although extremely low-frequency electric fields (ELF-EF) have been utilised for therapeutic purposes, the biological effect and the underlying mechanism of ELF-EF have not been elucidated. Here, we developed a mouse model of immobilisation-induced increase in glucocorticoid (GC) to evaluate the effect of ELF-EF. Mice were exposed to 50-Hz 10 kV/m EF via a parallel plate electrode and immobilised as needed. The ELF-EF suppressed the immobilisation-induced increase in blood GC level. Here, the results of 32 tests using the model were pooled and analysed. The suppressive effect of ELF-EF on immobilisation-induced increase in GC was reproduced, and the GC level was slightly higher in the ELF-EF-treated mice than in the sham-controlled mice, a novel observation. The immobilisation-induced increase in lactate dehydrogenase, glutamic oxaloacetic transaminase, and glutamic pyruvic transaminase, markers of tissue damage, was suppressed by co-treatment with EF in the biochemical tests using the same plasma sample. In the metabolome analysis, the changes in corticosterones, leukotrienes, and hydroxyeicosatetraenoic acids, markers of inflammation, showed a pattern similar to that of the plasma GC level. Thus, ELF-EF suppresses the stress response that causes an increase in the GC level and slightly promotes GC production in the absence of stress. Moreover, the suppressive effect of ELF-EF on induced stress response might be involved in stress-induced tissue damage or inflammation in immobilised mice. Overall, the model and the data help explore the biological effect of ELF-EF and explain the stress-relieving effect of EF. They would be useful in determining the medical applications of EF in humans and animals. | |||||||||
言語 | en | |||||||||
書誌情報 |
en : Scientific Reports 巻 10, p. 20930, 発行日 2020-12 |
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出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Nature Publishing Group | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | EISSN | |||||||||
収録物識別子 | 20452322 | |||||||||
DOI | ||||||||||
関連タイプ | isIdenticalTo | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | 10.1038/s41598-020-76106-1 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). | |||||||||
関連サイト | ||||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | https://doi.org/10.1038/s41598-020-76106-1 | |||||||||
関連名称 | https://doi.org/10.1038/s41598-020-76106-1 | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
日本十進分類法 | ||||||||||
主題Scheme | NDC | |||||||||
主題 | 649 |