WEKO3
アイテム
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Babesia gibsoni: An apical membrane antigen-1 homologue and its antibody response in the infected dogs
https://obihiro.repo.nii.ac.jp/records/447
https://obihiro.repo.nii.ac.jp/records/447bcc8dcb1-3701-4528-b156-69127588910f
名前 / ファイル | ライセンス | アクション |
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n070216-4.pdf (118.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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公開日 | 2007-02-19 | |||||||||||||
タイトル | ||||||||||||||
言語 | en | |||||||||||||
タイトル | Babesia gibsoni: An apical membrane antigen-1 homologue and its antibody response in the infected dogs | |||||||||||||
言語 | ||||||||||||||
言語 | eng | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | Babesia gibsoni | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | AMA-1 | |||||||||||||
キーワード | ||||||||||||||
言語 | en | |||||||||||||
主題Scheme | Other | |||||||||||||
主題 | antibody response | |||||||||||||
資源タイプ | ||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
資源タイプ | journal article | |||||||||||||
著者 |
Zhou, Jinlin
× Zhou, Jinlin× Yang, Jun× Zhang, Guohong× 西川, 義文
WEKO
176
× Fujisaki, Kozo× 玄, 学南
WEKO
295
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抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | A cDNA encoding the apical membrane antigen-1 (AMA-1) homologue was obtained by immunoscreening a cDNA expression library prepared from Babesia gibsoni merozoite mRNA. The complete nucleotide sequence of the gene was 2062 bp. Computer analysis suggested that the sequence contains an open reading frame of 1794 bp with a coding capacity of approximately 66 kDa. Based on the homology analysis, this putative protein was designated as B. gibsoni AMA-1 (BgAMA-1). The BgAMA-1 gene was expressed in the Escherichia coli BL21 strain and used as the antigen in Western blotting and the enzyme-linked immunosorbent assay (ELISA). The results indicated that BgAMA-1 was recognized as an immunodominant antigen by the host immune system and that it induced a strong antibody response only in chronic B. gibsoni infection in dogs; however, the antibody response could not be detected in the early infection stage (within 15 days). This phenomenon might be explained by the limited stimulation with the low-abundance protein in the early infection stage. This result shows that BgAMA-1 is a new member of the AMA-1 family and that its immune response is characteristic of canine B. gibsoni infection. | |||||||||||||
言語 | en | |||||||||||||
書誌情報 |
en : Experimental Parasitology 巻 114, 号 4, p. 329-333, 発行日 2006-12 |
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出版者 | ||||||||||||||
言語 | en | |||||||||||||
出版者 | Elsevier | |||||||||||||
ISSN | ||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||
収録物識別子 | 00144894 | |||||||||||||
書誌レコードID | ||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||
収録物識別子 | AA00641226 | |||||||||||||
権利 | ||||||||||||||
言語 | en | |||||||||||||
権利情報 | Elsevier | |||||||||||||
フォーマット | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | application/pdf | |||||||||||||
著者版フラグ | ||||||||||||||
出版タイプ | VoR | |||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |