WEKO3
アイテム
{"_buckets": {"deposit": "6c16fe11-e22e-43ee-82ce-75d4fb1d4fb0"}, "_deposit": {"created_by": 12, "id": "4336", "owners": [12], "pid": {"revision_id": 0, "type": "depid", "value": "4336"}, "status": "published"}, "_oai": {"id": "oai:obihiro.repo.nii.ac.jp:00004336", "sets": ["5"]}, "author_link": ["255", "379", "6173"], "item_2_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "64", "bibliographicVolumeNumber": "20", "bibliographic_titles": [{"bibliographic_title": "International Journal of Molecular Sciences", "bibliographic_titleLang": "en"}]}]}, "item_2_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_2_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Although epidemiological and experimental studies have suggested beneficial effects of vitamin E deficiency on malaria infection, it has not been clinically applicable for the treatment of malaria owing to the significant content of vitamin E in our daily food. However, since α-tocopherol transfer protein (α-TTP) has been shown to be a determinant of vitamin E level in circulation, manipulation of α-tocopherol levels by α-TTP inhibition was considered as a potential therapeutic strategy for malaria. Knockout studies in mice indicated that inhibition of α-TTP confers resistance against malaria infections in murines, accompanied by oxidative stress-induced DNA damage in the parasite, arising from vitamin E deficiency. Combination therapy with chloroquine and α-TTP inhibition significantly improved the survival rates in murines with malaria. Thus, clinical application of α-tocopherol deficiency could be possible, provided that α-tocopherol concentration in circulation is reduced. Probucol, a recently found drug, induced α-tocopherol deficiency in circulation and was effective against murine malaria. Currently, treatment of malaria relies on the artemisinin-based combination therapy (ACT); however, when mice infected with malarial parasites were treated with probucol and dihydroartemisinin, the beneficial effect of ACT was pronounced. Protective effects of vitamin E deficiency might be extended to manage other parasites in future. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_2_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI", "subitem_publisher_language": "en"}]}, "item_2_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.3390/ijms20010064", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is an open access article licensed under the terms of the Creative Commons Attribution (by) License. \u003chttp://creativecommons.org/lisenses/by/4.0/\u003e", "subitem_rights_language": "en"}]}, "item_2_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "16616596", "subitem_source_identifier_type": "PISSN"}]}, "item_2_subject_21": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "649", "subitem_subject_scheme": "NDC"}]}, "item_2_text_25": {"attribute_name": "文献提供者", "attribute_value_mlt": [{"subitem_text_value": "鈴木宏志 hisuzuki@obihiro.ac.jp"}]}, "item_2_textarea_24": {"attribute_name": "作業記録", "attribute_value_mlt": [{"subitem_textarea_value": "Scopus201902-09; 2019/2/20鈴木先生に依頼(CC BY); 2019/2/20 OK; 2019/3/14登録; \n"}]}, "item_2_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "255", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000003006849", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000003006849"}, {"nameIdentifier": "60333473", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60333473"}]}, {"creatorNames": [{"creatorName": "Kume, Aiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "379", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000003062455", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000003062455"}]}, {"creatorNames": [{"creatorName": "Herbas, Marua Shirely", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6173", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-03-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ijms-20-00064.pdf", "filesize": [{"value": "871.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 871600.0, "url": {"label": "full text", "url": "https://obihiro.repo.nii.ac.jp/record/4336/files/ijms-20-00064.pdf"}, "version_id": "4d5634bb-a142-4978-8ce7-593f2a380afd"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Artemisinin-based combination therapy (ACT)", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Chloroquine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oxidative stress", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Probucol", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Vitamin E", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "α-tocopherol", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "α-tocopherol transfer protein (α-TTP)", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Potential of vitamin E deficiency, induced by inhibition of α-tocopherol efflux, in murine malaria infection", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Potential of vitamin E deficiency, induced by inhibition of α-tocopherol efflux, in murine malaria infection", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "12", "path": ["5"], "permalink_uri": "https://obihiro.repo.nii.ac.jp/records/4336", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-03-14"}, "publish_date": "2019-03-14", "publish_status": "0", "recid": "4336", "relation": {}, "relation_version_is_last": true, "title": ["Potential of vitamin E deficiency, induced by inhibition of α-tocopherol efflux, in murine malaria infection"], "weko_shared_id": -1}
Potential of vitamin E deficiency, induced by inhibition of α-tocopherol efflux, in murine malaria infection
https://obihiro.repo.nii.ac.jp/records/4336
https://obihiro.repo.nii.ac.jp/records/4336f7d4f06c-5879-451d-ad7d-e3c1a6b989e2
名前 / ファイル | ライセンス | アクション |
---|---|---|
full text (871.6 kB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-03-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Potential of vitamin E deficiency, induced by inhibition of α-tocopherol efflux, in murine malaria infection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Artemisinin-based combination therapy (ACT) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Chloroquine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Oxidative stress | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Probucol | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Vitamin E | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | α-tocopherol | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | α-tocopherol transfer protein (α-TTP) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Suzuki, Hiroshi
× Suzuki, Hiroshi× Kume, Aiko× Herbas, Marua Shirely |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although epidemiological and experimental studies have suggested beneficial effects of vitamin E deficiency on malaria infection, it has not been clinically applicable for the treatment of malaria owing to the significant content of vitamin E in our daily food. However, since α-tocopherol transfer protein (α-TTP) has been shown to be a determinant of vitamin E level in circulation, manipulation of α-tocopherol levels by α-TTP inhibition was considered as a potential therapeutic strategy for malaria. Knockout studies in mice indicated that inhibition of α-TTP confers resistance against malaria infections in murines, accompanied by oxidative stress-induced DNA damage in the parasite, arising from vitamin E deficiency. Combination therapy with chloroquine and α-TTP inhibition significantly improved the survival rates in murines with malaria. Thus, clinical application of α-tocopherol deficiency could be possible, provided that α-tocopherol concentration in circulation is reduced. Probucol, a recently found drug, induced α-tocopherol deficiency in circulation and was effective against murine malaria. Currently, treatment of malaria relies on the artemisinin-based combination therapy (ACT); however, when mice infected with malarial parasites were treated with probucol and dihydroartemisinin, the beneficial effect of ACT was pronounced. Protective effects of vitamin E deficiency might be extended to manage other parasites in future. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | |||||
言語 | en | |||||
書誌情報 |
en : International Journal of Molecular Sciences 巻 20, 号 1, p. 64, 発行日 2019 |
|||||
出版者 | ||||||
言語 | en | |||||
出版者 | MDPI | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 16616596 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3390/ijms20010064 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is an open access article licensed under the terms of the Creative Commons Attribution (by) License. <http://creativecommons.org/lisenses/by/4.0/> | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 649 |