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Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells
https://obihiro.repo.nii.ac.jp/records/4264
https://obihiro.repo.nii.ac.jp/records/4264f6be98f7-b594-4ec4-8b11-215144fc58ce
名前 / ファイル | ライセンス | アクション |
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full text (2.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2018-10-25 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Talukder, Anup Kumar
× Talukder, Anup Kumar× Rashid, Mohammad B.× Yousef, Mohamed Samy× Kusama, Kazuya× Shimizu, Takashi× Shimada, Masayuki× Suarez, Susan S.× Imakawa, Kazuhiko× Miyamoto, Akio
WEKO
151
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Recent studies indicate that communication between the bovine embryo and the mother begins in the oviduct. Here, we aimed to investigate the effect of embryos on bovine oviducts for their immune responses using an in vitro model. First, zygotes were cultured with or without bovine oviduct epithelial cells (BOECs) for 4 days, when embryos had reached the 16-cell stage. At that time, we detected interferon-tau (IFNT) in embryos co-cultured with BOECs, but not in embryos cultured alone. Next, peripheral blood mononuclear cells (PBMCs) were incubated either in media from embryo alone cultures or from co-cultures of embryos with BOECs. The medium from embryo alone cultures did not modulate PBMCs gene expression; whereas the embryo-BOEC co-culture medium increased interferon-stimulated genes (ISGs: ISG15, OAS1, MX2), STAT1, PTGES and TGFB1 but suppressed IL17 expression in PBMCs. Both IFNT-treated BOEC culture medium and IFNT-supplemented fresh medium alone without BOEC, modulated PBMCs gene expressions similar to those by the embryo-BOEC co-culture medium. Further, specific antibody to IFNT neutralized the effect of embryo-BOEC co-culture medium on PBMCs gene expression. Our results indicate that BOECs stimulate embryos to produce IFNT, which then acts on immune cells to promote an anti-inflammatory response in the oviduct. © 2018 The Author(s). | |||||||
言語 | en | |||||||
書誌情報 |
en : Scientific Reports 巻 8, 号 1, p. 7850, 発行日 2018 |
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出版者 | ||||||||
言語 | en | |||||||
出版者 | Nature Publishing Group | |||||||
ISSN | ||||||||
収録物識別子タイプ | PISSN | |||||||
収録物識別子 | 20452322 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | info:doi/http://doi.org/10.1038/s41598-018-26224-8 | |||||||
権利 | ||||||||
言語 | en | |||||||
権利情報 | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
日本十進分類法 | ||||||||
主題Scheme | NDC | |||||||
主題 | 645 |