WEKO3
アイテム
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Human milk oligosaccharides as essential tools for basic and application studies on galectins
https://obihiro.repo.nii.ac.jp/records/4185
https://obihiro.repo.nii.ac.jp/records/41854b232a4a-c64f-4f7b-a7da-67ba844c3bf6
名前 / ファイル | ライセンス | アクション |
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fulltext (5.0 MB)
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Supplementary material (300.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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公開日 | 2018-03-28 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Human milk oligosaccharides as essential tools for basic and application studies on galectins | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Galectin binding specificity | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Galectins | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | HMO biosynthesis | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | HMO core structures | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | HMOs | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | HMOs dataset | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Human milk oligosaccharides | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Milk oligosaccharides | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
浦島, 匡
× 浦島, 匡
WEKO
291
× Hirabayashi, Jun× Sato, Sachiko× Kobata, Akira |
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | It is now recognized that human milk oligosaccharides (HMOs) can function both as prebiotics and as decoy receptors that inhibit the attachment of pathogenic microorganisms to the colonic mucosa. They can also act as immune modulators and as colonic maturation stimulators in breast-fed infants. These functions could be mediated by biological interaction between a variety of HMOs and lectins including galectins, selectins and siglecs. There are more than 100 HMOs; they have structural units such as H type 1: Fucα1-2Galβ1-3GlcNAc, Lewis a: Galβ1-3(Fucα1-4)GlcNAc, Lewis b: Fucα1-2Galβ1-3(Fucα1-4)GlcNAc, Lewis x: Galβ1-4(Fuc α1-3)GlcNAc, sialyl Lewis a: Neu5Acα2-3Galβ1-3(Fucα1-4)GlcNAc, and sialyl Lewis x: Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAc. It can be expected that these units may be utilized as tools for studies on the sugar-binding specificities of lectins including galectins, monoclonal antibodies, virus capsid proteins and bacterial toxins. This mini-review presents the dataset of comprehensive HMO structures, including recently clarified ones, in tabular form, for its utilization in such studies, including those of carbohydrate-binding specificity of galectins. In addition, this review introduces recent in vivo and clinical studies, which may be relevant to the biological functions and future utilization of HMOs. © 2018 FCCA (Forum: Carbohydrates Coming of Age). | |||||||||
言語 | en | |||||||||
書誌情報 |
en : Trends in Glycoscience and Glycotechnology 巻 30, 号 172, p. SE51-SE65, 発行日 2018-01-25 |
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出版者 | ||||||||||
言語 | en | |||||||||
出版者 | FCCA(Forum: Carbohydrates Coming of Age) | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
収録物識別子 | 09157352 | |||||||||
書誌レコードID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA10995236 | |||||||||
DOI | ||||||||||
関連タイプ | isIdenticalTo | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | info:doi/10.4052/tigg.1734.1SE | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
日本十進分類法 | ||||||||||
主題Scheme | NDC | |||||||||
主題 | 489 |