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Identification and characterization of cross-reactive antigens from Neospora caninum and Toxoplasma gondii
https://obihiro.repo.nii.ac.jp/records/354
https://obihiro.repo.nii.ac.jp/records/3549c11fb21-4a97-46d1-8ed7-998be6eead43
名前 / ファイル | ライセンス | アクション |
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n070216-5.pdf (269.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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公開日 | 2007-02-19 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Identification and characterization of cross-reactive antigens from Neospora caninum and Toxoplasma gondii | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Neospora caninum | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Toxoplasma gondii | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | cross-reactive antigen | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | protein disulfide isomerase | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | heat-shock protein | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | ribosomal protein 1 | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | journal article | |||||||||
著者 |
Liao, Min
× Liao, Min× 玄, 学南
WEKO
295
× Huang, Xiaohong× Shirafuji, Hiroaki× 福本, 晋也× Hirata, Haruyuki× Suzuki, Hiroshi× Fujisaki, Kozo |
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Murine monoclonal antibodies (mAbs) against Neospora caninum tachyzoites were produced to identify the cross-reactive antigens between N. caninum and Toxoplasma gondii. Ten mAbs recognizing cross-reactive antigens of both parasites were obtained and tentatively classified into 6 different groups based on their reactivity patterns in an indirect fluorescent antibody test and Western blot analysis. Three mAbs in group I recognized antigens located on the surface of parasites with molecular masses ranging from 28 to 76 kDa; one mAb in group 2 recognized antigens located on interior organelles of parasites with a molecular mass of 50 kDa; one mAb in group 3 recognized antigens located on interior organelles of parasites with molecular masses of 35 kDa and 14 kDa; three mAbs in group 4 recognized antigens located on interior organelles with a molecular mass of 64 kDa; one mAb in group 5 recognized antigens located on the surface of parasites with an unknown molecular mass; one mAb in group 6 recognized antigens located on the apical end of parasites with an unknown molecular mass. The mAbs in groups 1, 2, 3, and 5 showed inhibitory effects on the growth of the two parasites in vitro in a dose-dependent manner. A cDNA expression library prepared from N. caninum tachyzoite mRNA was immunoscreened with the mAb panel. Three kinds of proteins, protein disulfide isomerase (PDI), heat-shock protein 70 (HSP70), and ribosomal protein 1 (RP1), were identified as cross-reactive antigens recognized by mAbs in groups 2, 3, and 4, respectively. Some of the proteins could be useful in developing vaccines or drugs for controlling the diseases caused by the two parasites. | |||||||||
言語 | en | |||||||||
書誌情報 |
en : Parasitology 巻 130, p. 481-488, 発行日 2005-05 |
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出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Cambridge University Press | |||||||||
ISSN | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
収録物識別子 | 00311820 | |||||||||
書誌レコードID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA00769354 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | Cambridge University Press | |||||||||
フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |