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チオレドキシンペルオキシダーゼがマラリア原虫の宿主寄生適応に果たす役割の解明
https://obihiro.repo.nii.ac.jp/records/3047
https://obihiro.repo.nii.ac.jp/records/30479f759519-5512-4dae-8ac6-a625e77909bb
名前 / ファイル | ライセンス | アクション |
---|---|---|
20390118seika.pdf (460.5 kB)
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|
Item type | 報告書 / Research Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-07-29 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | チオレドキシンペルオキシダーゼがマラリア原虫の宿主寄生適応に果たす役割の解明 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 感染症 | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | マラリア | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | ストレス | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | レドックス | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 遺伝子改変原虫 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
その他(別言語等)の研究課題名 | ||||||
その他のタイトル | Analysis of the roles of thioredoxin peroxidase family for adaptation to oxidative stresses in malaria parasites | |||||
言語 | en | |||||
研究代表者 |
河津, 信一郎
× 河津, 信一郎 |
|||||
研究分担者 | ||||||
姓名 | Kanuka, Hirotaka | |||||
言語 | en | |||||
姓名 | 嘉糠, 洋陸 | |||||
言語 | ja | |||||
所属機関識別子Scheme | ISNI | |||||
所属機関識別子URI | http://www.isni.org/isni/ | |||||
言語 | ja | |||||
研究分担者 | ||||||
姓名 | 鳥居, 本美 | |||||
言語 | ja | |||||
研究分担者 | ||||||
姓名 | 新井, 明治 | |||||
言語 | ja | |||||
研究課題番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 20390118 | |||||
研究代表者番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 60312295 | |||||
研究機関 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 帯広畜産大学 | |||||
言語 | ja | |||||
助成元 | ||||||
ja | ||||||
科学研究費助成事業 | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | チオレドキシンペルオキシダーゼ2-Cys型Prx遺伝子を欠損するローデント(ネズミ)マラリア原虫について、これまでに観察された表現型発現のメカニズムを調べた。(1)哺乳類赤血球内でのガメートサイト(生殖母体)の分化誘導・形成阻害について:赤内期原虫タンパク質の二次元電気泳動解析から、この表現型にタンパク質リン酸化が関与することが示唆された。また(2)スポロゾイト(感染型原虫)の哺乳類宿主への感染性の低下について:マウス感染モデルを用いたRT-PCR解析から、この表現型が、スポロゾイトの障害ではなく、肝内型原虫の発育阻害に起因することが示唆された。 | |||||
言語 | ja | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Phenotypes observed in the rodent malaria parasite Plasmodium berghei carrying a targeted knockout of thioredoxin peroxidase, 2-Cys peroxiredoxin gene were investigated and have the following results: (1) Defect in the gametocyte (sexual stage for transition to mosquitoes) development: 2D-PAGE analysis of the blood-stage parasite proteins suggested that the defect is attributed to the protein phosphorylation; (2) Extension in the prepatent time in the sporozoite (infective stage to mammalian hosts from mosquitoes) infection: RT-PCR analysis of the experimental infections suggested that the knockout did not have any effect on the infectivity of the sporozoite, but it affects the development of the liver-stage (EEF) in the mice. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2008年度~2010年度科学研究費補助金基盤研究(B)研究成果報告書 | |||||
言語 | ja | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |